Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex.

Addiction Biology
Osnat Ben-ShaharNick Woodward

Abstract

Previous studies have shown that brief access to cocaine yields an increase in D2 receptor binding in the medial prefrontal cortex (mPFC), but that extended access to cocaine results in normalized binding of D2 receptors (i.e. the D2 binding returned to control levels). Extended-access conditions have also been shown to produce increased expression of the NR2 subunit of the N-Methyl-D-aspartate receptor in the mPFC. These results implicate disrupted glutamate and dopamine function within this area. Therefore, in the present study, we monitored glutamate and dopamine content within the mPFC during, or 24 hours after, cocaine self-administration in animals that experienced various amounts of exposure to the drug. Naïve subjects showed decreased glutamate and increased dopamine levels within the mPFC during cocaine self-administration. Exposure to seven 1-hour daily cocaine self-administration sessions did not alter the response to self-administered cocaine, but resulted in decreased basal dopamine levels. While exposure to 17 1-hour sessions also resulted in reduced basal dopamine levels, these animals showed increased dopaminergic, but completely diminished glutamatergic, response to self-administered cocaine. Finally, exposure ...Continue Reading

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Citations

May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexis W AryKaren K Szumlinski
Jan 16, 2016·Addiction Biology·Bailey W MillerKaren K Szumlinski
Nov 3, 2015·Neuropharmacology·Christina B ShinKaren K Szumlinski
Feb 24, 2015·Brain Research·William C Buchta, Arthur C Riegel
Jan 8, 2016·The European Journal of Neuroscience·Kevin D LominacKaren K Szumlinski
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Jun 29, 2013·Neuroscience and Biobehavioral Reviews·Wendy J LynchMark A Smith
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Oct 11, 2017·Pharmacological Reports : PR·Lucyna Pomierny-ChamioloMalgorzata Filip
Aug 26, 2019·Psychopharmacology·Christina Gobin, Marek Schwendt

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