Extended ceftiofur therapy for treatment of experimentally-induced Streptococcus uberis mastitis in lactating dairy cattle

Journal of Dairy Science
Stephen P OliverW M Moseley

Abstract

Streptococcus uberis is an important cause of mastitis in dairy cows throughout the world, particularly during the dry period, the period around calving, and during early lactation. Strategies for controlling Strep. uberis mastitis are poorly defined and are currently inadequate. Objectives of the present study were to evaluate efficacy of ceftiofur, a new broad-spectrum cephalosporin antibiotic, for treatment of experimentally induced Strep. uberis intramammary infections (IMI) in lactating dairy cows during early lactation and to determine whether extended therapy regimens enhanced efficacy of ceftiofur. Efficacy of extended ceftiofur intramammary therapy regimens was investigated in 37 mammary quarters of 23 dairy cows that developed clinical mastitis following experimental infection with Strep. uberis during early lactation. Cows that developed clinical mastitis during the challenge period were allocated randomly to 3 groups representing 3 different ceftiofur treatment regimens: 2-d (n = 7 mammary quarters), 5-d (n = 16 mammary quarters), and 8-d (n = 14 mammary quarters) treatment regimens. For all groups, 125 mg of ceftiofur hydrochloride was administered via intramammary infusion. A bacteriological cure was defined as an...Continue Reading

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Citations

Jan 1, 2009·Irish Veterinary Journal·S Pyörälä
Sep 15, 2015·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·E M Mansion-de VriesV Krömker
Oct 17, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·S AsafZ Roth
Nov 11, 2015·Journal of Bacteriology·Saswati BiswasIndranil Biswas
Feb 16, 2015·Journal of Dairy Science·J M SwinkelsT J G M Lam
Aug 21, 2013·Journal of Dairy Science·Z RothG Leitner
Apr 22, 2008·Tropical Animal Health and Production·Sabry A El-Khodery, Salama A Osman
Aug 18, 2017·Reproduction in Domestic Animals = Zuchthygiene·V Krömker, S Leimbach
Jan 30, 2021·The Veterinary Quarterly·Khan SharunWanpen Chaicumpa
May 25, 2021·Frontiers in Veterinary Science·Regitze Renee PedersenElin Jørgensen

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