Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation

Expert Review of Gastroenterology & Hepatology
Balázs NemesSusumu Eguchi

Abstract

Extended-criteria donors (ECDs) have an impact on early allograft dysfunction (EAD), biliary complications, relapse of hepatitis C virus (HCV), and survivals. Early allograft dysfunction was frequently seen in grafts with moderate and severe steatosis. Donors after cardiac death (DCD) have been associated with higher rates of graft failure and biliary complications compared to donors after brain death. Extended warm ischemia, reperfusion injury and endothelial activation trigger a cascade, leading to microvascular thrombosis, resulting in biliary necrosis, cholangitis, and graft failure. The risk of HCV recurrence increased by donor age, and associated with using moderately and severely steatotic grafts. With the administration of protease inhibitors sustained virological response was achieved in majority of the patients. Donor risk index and EC donor scores (DS) are reported to be useful, to assess the outcome. The 1-year survival rates were 87% and 40% respectively, for donors with a DS of 0 and 3. Graft survival was excellent up to a DS of 2, however a DS >2 should be avoided in higher-risk recipients. The 1, 3 and 5-year survival of DCD recipients was comparable to optimal donors. However ECDs had minor survival means of 85...Continue Reading

References

Dec 1, 2001·Annals of Surgery·D C BroeringX Rogiers
Sep 26, 2003·Clinics in Liver Disease·Aaron C Baltz, James F Trotter
Dec 20, 2003·Annals of Surgery·Peter L AbtJames F Markmann
Dec 16, 2004·Pediatric Transplantation·J S KimX Rogiers
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·John R LakeRussell H Wiesner
Jan 24, 2006·Lancet·Andrew K BurroughsUNKNOWN European Liver Transplant Association
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N R BarshesJ A Goss
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maud BessemsThomas M van Gulik
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jean F BothaAlan N Langnas
Jul 10, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P G NorthupT M Schmitt
Sep 25, 2007·Transplantation Proceedings·J BriceñoS Rufián
Nov 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arash NickkholghPeter Schemmer
Nov 29, 2007·Annals of Surgery·Lucas McCormackPierre-Alain Clavien
Dec 25, 2007·American Journal of Surgery·Martin K AngeleFlorian Loehe
Feb 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Salvatore GruttadauriaBruno Gridelli
Feb 29, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard S MangusA Joseph Tector
Apr 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P DutkowskiP-A Clavien
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Edie Y ChanAdam E Levy
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Katrien VekemansDiethard Monbaliu
Aug 5, 2008·Transplantation Proceedings·I PetridisB Gridelli
Aug 20, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·Telesforo BacchellaMarcel Cerqueira César Machado
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina Berenguer
Dec 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nevin Yilmaz, Mitchell L Shiffman
Dec 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javier BriceñoPedro López-Cillero
Feb 18, 2009·Clinical Transplantation·Justin H NguyenChristopher B Hughes
Mar 21, 2009·Transplantation·Huda M NoujaimTercio Genzini
May 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrizia BurraMassimo Rugge
Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A FranchelloM Salizzoni
Jun 23, 2009·The Journal of Surgical Research·Judith StegemannThomas Minor
Sep 26, 2009·Surgery Today·Sherilyn Gordon Burroughs, Ronald W Busuttil
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Lei YuGeorge Ioannou
Nov 3, 2009·Clinical Transplantation·Umberto BaccaraniFabrizio Bresadola
Nov 21, 2009·Clinical Transplantation·Maria Trinidad SerranoJuan J Araiz
Dec 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J V GuarreraJ C Emond

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Citations

Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R Cutler Quillin, James V Guarrera
Sep 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SchlegelP Dutkowski
May 18, 2017·Journal of Surgical Oncology·Dimitrios MorisTimothy M Pawlik
Apr 8, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jasmijn W SeltenLuc J W van der Laan
Sep 28, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Sebastian PratschkeUNKNOWN Eurotransplant Liver and Intestine Advisory Committee (ELIAC)
Jan 23, 2020·International Journal of Molecular Sciences·Lina JakubauskienePeter Schemmer
Feb 21, 2018·Current Opinion in Organ Transplantation·Constance M Mobley, Ashish Saharia
May 14, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Damien DousseNicolas Golse
May 2, 2018·World Journal of Gastroenterology : WJG·Ágnes Lilla SzilágyiPetra Hartmann
Nov 8, 2017·Current Transplantation Reports·Negin Karimian, Heidi Yeh
Sep 28, 2016·World Journal of Gastroenterology : WJG·Elisabetta LoggiPietro Andreone
Dec 27, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R Cutler Quillin, James V Guarrera
Jan 31, 2019·World Journal of Transplantation·Yuri L Boteon, Simon C Afford
Feb 23, 2019·The Journal of International Medical Research·Jun-Jun JiaShu-Sen Zheng
Feb 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Masoud MazaheriFarahnaz Sadegh Beigee
Aug 23, 2020·International Journal of Molecular Sciences·Raji BaidyaKim R Bridle
Oct 18, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Isabel M A BrüggenwirthRobert J Porte
Nov 21, 2020·Langenbeck's Archives of Surgery·Julian MichelottoNathanael Raschzok
Jul 21, 2020·Clinical Transplantation·Yuki KitanoRené Adam
Nov 26, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michel RayarBernard Meunier
May 25, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Thijmen VisserenUNKNOWN European Liver and Intestine Transplantation Association (ELITA)
Aug 12, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ola AhmedWilliam C Chapman

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