Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex.

Osnat Ben-ShaharKaren K Szumlinski


Human cocaine addicts show altered function within the basal ganglia and the medial prefrontal cortex (mPFC) and altered glutamate function within these areas is postulated to be critical for cocaine addiction. The present project utilized a highly valid animal model of cocaine addiction, to test whether excessive use of cocaine alters glutamate function within these brain areas. Rats were trained to lever-press for i.v. saline vehicle or cocaine (0.25 mg/infusion) over seven 1-h daily sessions, after which, saline controls and half of cocaine self-administering animals (brief access condition) received 10 more 1-h daily sessions, whereas the remaining cocaine animals received 10 additional 6-h daily sessions (extended access condition). One, 14, or 60 days after the last self-administration session, animals were sacrificed. Tissue samples from the ventral tegmental area (VTA), nucleus accumbens (N.Acc) core and shell, and mPFC were analyzed by immunoblotting for expression of Homer1b/c, Homer2a/b, mGluR1, mGluR5, NR2a, and NR2b subunits of the NMDA receptor. Brief and extended access to cocaine failed to alter protein levels within the VTA, and produced transient and similar changes in N.Acc protein expression, which were more...Continue Reading


Jul 1, 1992·Synapse·N D VolkowL Handlesman
Dec 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·E T RollsJ McGrath
Mar 1, 1993·The American Journal of Psychiatry·N D VolkowS L Dewey
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R Damasio
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Oct 26, 2002·Science·Morgan Sheng, Myung Jong Kim
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Mar 26, 2003·Psychopharmacology·Peter W Kalivas, Krista McFarland
Apr 30, 2003·Journal of Neurochemistry·Wen-Xue TangScott E Hemby
Nov 20, 2003·Neuroreport·Neil E Paterson, Athina Markou
Dec 20, 2003·Annals of the New York Academy of Sciences·Charles Dackis, Charles O'Brien
May 8, 2004·Science·H F ClarkeA C Roberts
Jul 15, 2004·Annals of the New York Academy of Sciences·Ann E KelleyCharles F Landry
Aug 6, 2004·Neuron·Karen K SzumlinskiPeter W Kalivas
Oct 7, 2004·Neuropharmacology·Terry E Robinson, Bryan Kolb

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