Extended enhancement of corticospinal connectivity with concurrent cortical and peripheral stimulation controlled by sensorimotor desynchronization

Brain Stimulation
Robert GuggenbergerAlireza Gharabaghi

Abstract

Pairing cortical and peripheral input during motor imagery (MI)-related sensorimotor desynchronization (ERD) modulates corticospinal excitability at the cortical representation (hotspot) of the imagined movement. To determine the effects of this associative stimulation protocol on the cortical motor map beyond the hotspot. In healthy subjects, peripheral stimulation through passive hand opening by a robotic orthosis and single-pulse transcranial magnetic stimulation to the respective cortical motor representation were applied in a brain-machine interface environment. State-dependency was investigated by concurrent, delayed or non-specific stimulation with respect to ERD in the beta-band (16-22 Hz) during MI of finger extension. Concurrent stimulation led to increased excitability of an extended motor map. Delayed and non-specific stimulation led to heterogeneous changes, i.e., opposite patterns of increased excitability in either the center or the periphery of the motor map. These results could be instrumental in closed-loop, state-dependent stimulation in the context of neurorehabilitation.

Citations

Sep 10, 2019·The Journal of Physiology·Richard G Carson, Alison R Buick
Apr 9, 2020·The Journal of Physiology·K M Riashad Foysal, Stuart N Baker
Jun 18, 2019·Cerebral Cortex·Georgios NarosAlireza Gharabaghi
Aug 1, 2020·Frontiers in Bioengineering and Biotechnology·Robert GuggenbergerAlireza Gharabaghi
Oct 30, 2020·Frontiers in Bioengineering and Biotechnology·Robert GuggenbergerAlireza Gharabaghi
Apr 20, 2021·Frontiers in Neuroscience·Laura J ArendsenAlireza Gharabaghi

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