Extended excretion of rotavirus after severe diarrhoea in young children

Lancet
S RichardsonRuth Bishop

Abstract

Rotaviruses are the major cause of severe childhood diarrhoea. Knowledge of the natural history of infection, including duration of intestinal virus shedding, is important in the understanding of transmission, sources of infection, and immune responses. We carried out a study of rotavirus excretion in 37 children admitted to hospital with severe rotavirus diarrhoea. Sequential faecal specimens were collected from each child during 100 days of surveillance, and screened for rotavirus by EIA and by amplification of genome double-stranded RNA by reverse-transcription PCR. IgA coproantibody was estimated by EIA. Duration of rotavirus excretion ranged from 4 to 57 days after onset of diarrhoea. Excretion ceased within 10 days in 16 (43%) children, and within 20 days in 26 (70%) children. Extended excretion was detected for 25-57 days in the remaining 11 (30%) children owing mainly to continued excretion of the primary infecting strain. Extended excretion was significantly associated with antirotavirus IgA coproantibody boosts during 100 days of surveillance (p=0.001, log-rank test), and with recurrence of mild diarrhoea symptoms during convalescence (p=0.006, Fisher's exact test). Severe rotavirus disease in young children may be fo...Continue Reading

References

Apr 1, 1975·Journal of Clinical Pathology·G P DavidsonB J Ruck
Jan 1, 1990·Journal of Virological Methods·L XuM A McCrae
Feb 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·K HjeltP A Krasilnikoff
Nov 1, 1973·The Journal of Infectious Diseases·E D Kilbourne
Jan 1, 1984·Journal of Medical Virology·F StalsC A Bruggeman
Jan 1, 1980·Archives of Virology·M K Estes, D Y Graham
Sep 1, 1981·Acta paediatrica Scandinavica·T VesikariM Mäki
Jan 1, 1984·Journal of Medical Virology·M J Albert, R F Bishop
Feb 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·A GuarinoA Casola

❮ Previous
Next ❯

Citations

Feb 12, 2004·The Lancet Infectious Diseases·Evan J Anderson, Stephen G Weber
Jul 10, 2001·Journal of Applied Microbiology·J BarkerS F Bloomfield
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A de WitY T van Duynhoven
Nov 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roy M Robins-Browne, Myron M Levine
Oct 7, 2006·Current Opinion in Gastroenterology·R D Shaw
Apr 17, 2001·The Pediatric Infectious Disease Journal·X L PangT Vesikari
Aug 2, 2002·The Pediatric Infectious Disease Journal·Vibeke RosenfeldtAnders Paerregaard
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Louis VernacchioDavid W K Acheson
Nov 30, 2012·The Pediatric Infectious Disease Journal·Jan A SidlerUlrich Heininger
May 15, 2008·Journal of the Royal Society, Interface·L J WhiteG F Medley
Oct 14, 2009·Journal of Gastroenterology and Hepatology·Ruth Bishop
Apr 25, 2006·Journal of Paediatrics and Child Health·Keith GrimwoodDiana R Lennon
Aug 24, 2006·Journal of Paediatrics and Child Health·Way S LeeSavithri D Puthucheary
Aug 10, 2012·Journal of Clinical Microbiology·Beatrix KapusinszkyEric Delwart
Mar 21, 2008·Journal of Clinical Microbiology·Lauren J StockmanUmesh D Parashar
Apr 28, 2006·Journal of Virology·Sue E CrawfordMary K Estes
Mar 23, 1999·Archives of Disease in Childhood·M Sood, I W Booth
Jul 3, 2010·Paediatric Drugs·Keith GrimwoodRichard J Milne
Sep 21, 2010·Uirusu·Osamu Nakagomi, Toyoko Nakagomi
Dec 25, 2009·Emerging Infectious Diseases·Nigel A CunliffeMartyn Regan
Nov 26, 2011·Clinical Reviews in Allergy & Immunology·Annick A J M van de VenJoris M van Montfrans
May 16, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M S CorcoranI H M van Loo
Apr 16, 2010·American Journal of Epidemiology·Gemma PhillipsClarence C Tam
May 23, 2012·The Journal of Infectious Diseases·Celeste M DonatoCarl D Kirkwood
Jul 14, 2009·Expert Opinion on Biological Therapy·Toyoko Nakagomi, Osamu Nakagomi
Apr 25, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shou-Chien ChenKow-Tong Chen
Sep 4, 2008·Journal of Virological Methods·S Q ZengT Vesikari
Sep 16, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carl D Kirkwood, Rick Streitberg
Jun 19, 2013·Journal of Medical Virology·Indrani MukhopadhyaGagandeep Kang
Aug 21, 2008·Journal of Medical Virology·Indrani BanerjeeGagandeep Kang
Mar 18, 2015·Journal of Medical Virology·Christina M OsborneSamuel R Dominguez
May 26, 2015·Clinics in Laboratory Medicine·Mathew D Esona, Rashi Gautam
Sep 15, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Noriki KamihiroMasakazu Inoue
Jul 13, 2014·Virus Research·Ulrich Desselberger
Jan 22, 2009·American Journal of Infection Control·Orith Waisbourd-ZinmanShai Ashkenazi
Feb 6, 2017·Journal of Virological Methods·S De GraziaG M Giammanco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.