PMID: 589558Dec 1, 1977

Extended field radiation therapy in Hodgkin's disease: analysis of failures

W B MillK O Franssila


A retrospective analysis of 116 primary cases of stage I, II and III-A Hodgkin's disease demonstrated 27 failures, fourteen confirmed by biopsy. Twenty of the 27 (74%) were in lymph node areas only and seven had extranodal extensions. The most frequent site of failure was the hilar nodes and contiguous lung. The majority of failures (78%) occurred within 30 months of treatment and the cause of failure determined in 23 (85%), sixteen of which were due to technical errors of irradiation. Analysis of the dosimetry in the mediastinal, hilar nodes and contiguous lung failures revealed three factors which may have contributed to a low dose. These factors are: 1) the equivalent square, 2) off-axis beam diminution, and 3) the anteroposterior dose profile. Combined radiation therapy and chemotherapy was more effective than either modality alone in the treatment of these failures.


Mar 1, 1977·Cancer·K O FranssilaH J Heiskala
Mar 1, 1976·Cancer Treatment Reviews·A M Mauer, J V Simone
May 1, 1976·Cancer·S S DonaldsonH S Kaplan
Jan 1, 1974·Cancer·M A Goldsmith, S K Carter
Dec 1, 1974·Cancer·J T BenjaminC W McMillan
Nov 7, 1974·The New England Journal of Medicine·N JaffeY Bishop
Jan 1, 1973·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J H CundiffN Suntharalingham
Mar 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·P RubinR Antemann
Sep 1, 1972·Clinical Pharmacology and Therapeutics·G P CannellosV T DeVita
Oct 1, 1971·Radiology·Y Maruyama, F M Khan
Dec 1, 1970·Annals of Internal Medicine·V T DeVitaP P Carbone


Jan 1, 1981·Acta Radiologica. Oncology·C E MerckeG O Svahn-Tapper
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·A P BrownJ W Wong
Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·A R TimothyA E Jones
Jan 1, 1984·Hematological Oncology·D Crowther
Mar 1, 1981·Clinical Radiology·A BarrettM J Peckham
May 15, 1981·Klinische Wochenschrift·W GassmannM Gluth-Stender

Related Concepts

Hodgkin Lymphoma, Lymphocyte Depletion
Lymph Nodes
Radiotherapy Dosage
Retrospective Studies

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