Extended follow-up of lung cancer and non-malignant respiratory disease mortality among California diatomaceous earth workers

Occupational and Environmental Medicine
Lisa G GallagherH Checkoway

Abstract

Millions of workers worldwide are employed in occupations involving potentiality hazardous exposure to crystalline silica. The diatomaceous earth industry can have particularly high exposures, but there is a lower likelihood of simultaneously occurring confounding exposures. We extended follow-up for diatomaceous earth industry workers previously studied for mortality. The cohort included 2342 white men who were employed for at least 1 year at a diatomaceous earth plant in Lompoc, California beginning in 1942. Workers' vital status was updated using the National Death Index through 2011, an extension of 19 years from earlier studies. Detailed work history and quantitative air monitoring measurements estimated exposure intensity. Cox proportional hazards modelling estimated HRs and 95% CIs. SMRs were calculated. Elevated mortality was observed by quartile of cumulative crystalline silica exposure for lung cancer (HR=2.03, 95% CI 1.07 to 3.85, highest quartile, unlagged) and non-malignant respiratory disease (NMRD) (HR=3.59, 95% CI 1.94 to 6.67, highest quartile, unlagged), although trends were not statistically significant. Associations were attenuated when adjusted for smoking and asbestos exposure. Mortality from NMRD was sign...Continue Reading

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Citations

Nov 13, 2015·Occupational and Environmental Medicine·Kenneth A Mundt, Paolo Boffetta
Sep 28, 2018·International Journal of Environmental Research and Public Health·Ching-Tang KuoTa-Yuan Chang
Feb 16, 2018·American Journal of Epidemiology·Andreas M NeophytouSadie Costello
Oct 14, 2019·Journal of Insect Science·Mohammad AkhoundiArezki Izri
May 11, 2021·Archives of Environmental & Occupational Health·Shivkumar S PrajapatiSarang V Dhatrak

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