PMID: 6401863Jan 1, 1983Paper

Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man

Proceedings of the National Academy of Sciences of the United States of America
Z L AwdehC A Alper

Abstract

The chromosomal distribution of alleles for HLA-A,-B,-C, and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families. Eight combinations of HLA-B, DR, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly higher than expected. In these combinations, which were defined as extended major histocompatibility complex haplotypes, HLA-A showed limited variation. A possible mechanism for the maintenance of extended haplotypes are human analogs of murine t mutants which are characterized by crossover suppression and male transmission bias. One human 6p haplotype, HLA-B8, DR3, SCO1, GLO 2, was found to be transmitted from males to 83% of their offspring. The same haplotype with GLO 1 had no transmission bias. It is suggested that this GLO 2-marked chromosome is a human analog of a murine t mutant.

References

Oct 6, 1979·Lancet·L R Weitkamp
Jan 1, 1979·Cytogenetics and Cell Genetics·T B ShowsK Weiss
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G J O'NeillB Dupont
Apr 1, 1976·Analytical Biochemistry·Z L Awdeh
Jan 1, 1972·The Journal of Experimental Medicine·C A AlperL Watson
Jan 1, 1974·Vox Sanguinis·F H Allen
Jan 5, 1980·Lancet·S Serjeantson
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Z L Awdeh, C A Alper

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Citations

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·P Blum, J Jankovic
Feb 1, 1997·Protein Science : a Publication of the Protein Society·S K Law, A W Dodds
Jan 1, 1992·Immunogenetics·R P WarrenM McCullough
Oct 1, 1989·Human Genetics·G GeserickH Schröder
Jan 1, 1985·Human Genetics·J R Regueiro, A Arnaiz-Villena
Jan 1, 1987·Immunogenetics·J GranadosC A Alper
Jan 1, 1987·Immunogenetics·M S KruskallE J Yunis
Jan 1, 1985·Immunogenetics·S Y YangE J Yunis
Jan 1, 1985·Immunogenetics·M A RobinsonT J Kindt
Jan 1, 1985·Immunogenetics·V M SkanesC M Giles
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T R WelchL S Beischel
Jun 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N A BishofP A Donnelly
Jan 1, 1986·Springer Seminars in Immunopathology·H H Shen, R J Winchester
Mar 1, 1989·Indian Journal of Pediatrics·R Rani, K K Mittal
Oct 6, 2006·Springer Seminars in Immunopathology·John B HarleyKenneth M Kaufman
Oct 17, 2009·Journal of Clinical Immunology·Javad MohammadiLennart Hammarström
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·M N BlumenthalR C Elston
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Apr 1, 1986·Human Immunology·K Artzt
Feb 1, 1987·Human Immunology·W KlitzG Thomson
Nov 1, 1987·Human Immunology·G Mueller-EckhardtC Mueller-Eckhardt
Aug 1, 1988·Human Immunology·C Van KerckhoveD N Glass
May 1, 1988·Human Immunology·S A RobbV Dubowitz

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