Extended International Normalized Ratio testing intervals for warfarin-treated patients

Journal of Thrombosis and Haemostasis : JTH
G D BarnesJ B Froehlich

Abstract

Essentials Warfarin typically requires International Normalized Ratio (INR) testing at least every 4 weeks. We implemented extended INR testing for stable warfarin patients in six anticoagulation clinics. Use of extended INR testing increased from 41.8% to 69.3% over the 3 year study. Use of extended INR testing appeared safe and effective. Background A previous single-center randomized trial suggested that patients with stable International Normalized Ratio (INR) values could safely receive INR testing as infrequently as every 12 weeks. Objective To test the success of implementation of an extended INR testing interval for stable warfarin patients in a practice-based, multicenter collaborative of anticoagulation clinics. Methods At six anticoagulation clinics, patients were identified as being eligible for extended INR testing on the basis of prior INR value stability and minimal warfarin dose changes between 2014 and 2016. We assessed the frequency with which anticoagulation clinic providers recommended an extended INR testing interval (> 5 weeks) to eligible patients. We also explored safety outcomes for eligible patients, including next INR values, bleeding events, and emergency department visits. Results At least one eligi...Continue Reading

References

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Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
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Citations

Oct 8, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Amanda R MargolisCheryl A Ray
May 23, 2020·Journal of Thrombosis and Thrombolysis·Geoffrey D BarnesTracy Minichiello
Jul 21, 2020·Internal and Emergency Medicine·Doris Barcellona, Francesco Marongiu
Nov 23, 2019·The Annals of Pharmacotherapy·Rebecca R SchoenAmanda R Margolis
Jun 10, 2020·Internal and Emergency Medicine·Daniela PoliUNKNOWN On the behalf of Italian Federation of Anticoagulation Clinics (FCSA)
Mar 2, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Tina DoMarie Renauer

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