Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol

Fertility and Sterility
Ahmed BadawyMohamed Eid

Abstract

To evaluate the outcome of long letrozole therapy for induction of ovulation in patients with clomiphene-resistant polycystic ovary syndrome (PCOS). Prospective randomized controlled study. University teaching hospital and a private practice. The study comprised 218 patients with clomiphene-resistant PCOS. Patients were randomly allocated to treatment with either long letrozole therapy (n = 108; 219 cycles) or short letrozole therapy (n = 110; 225 cycles). Number of growing and mature follicles, serum E(2) (pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage. The number of ovulating patients was greater in the long letrozole group (65.7% vs. 61.8%), but without statistical differences. The total numbers of follicles during stimulation was significantly greater in the long letrozole group (6.7 +/- 0.3 vs. 3.9 +/- 0.4). The numbers of follicles > or =14 mm and > or =18 mm were significantly greater in the long letrozole group. There was no significant difference in the pretreatment endometrial thickness or endometrial thickness at the time of hCG administration between the two groups. Pregnancy occurred in 28 of 225 cycles in the short group (12.4%) and 38 of 219 cycles (17.4%) in the long letr...Continue Reading

Citations

Jul 8, 2011·Archives of Gynecology and Obstetrics·Fatemeh RamezanzadehMaryam Baghrei
Oct 8, 2009·Current Opinion in Obstetrics & Gynecology·Stefano PalombaFulvio Zullo
May 12, 2010·International Journal of Clinical Practice·A B Motta
Nov 17, 2009·Reproductive Biomedicine Online·Nikolaos P PolyzosDavide Mauri
Apr 8, 2011·Clinical Endocrinology·Vivian Chi Yan Lee, William Ledger
Apr 18, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Hong HuangLorena Madrigal
Sep 5, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A RevelliP Anserini
Jul 1, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Usama M Fouda, Ahmed M Sayed
May 23, 2015·Expert Opinion on Pharmacotherapy·Morena Luigia RoccaMichele Morelli
Feb 16, 2015·Obstetrics and Gynecology Clinics of North America·Johanna Von Hofe, G Wright Bates
Feb 25, 2014·The Cochrane Database of Systematic Reviews·Sebastian FranikCindy Farquhar
Sep 21, 2011·The Medical Journal of Australia·Helena J TeedeUNKNOWN Guideline Development Groups
May 26, 2018·The Cochrane Database of Systematic Reviews·Sebastian FranikCindy Farquhar
May 10, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Esmée M BordewijkBen W Mol
Jul 2, 2010·Current Opinion in Obstetrics & Gynecology·Elizabeth A Pritts
Jul 9, 2010·Current Opinion in Obstetrics & Gynecology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.