Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes.

Mechanisms of Ageing and Development
A J HulbertRochelle Buffenstein

Abstract

Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically heterogenous laboratory line of mice (DC). We have examined whether membrane fatty composition varies with lifespan within the species Mus musculus in a similar manner to that previously demonstrated between mammal species. Muscle and liver phospholipids from these long-living mice lines have a reduced amount of the highly polyunsaturated omega-3 docosahexaenoic acid compared to the DC mice, and consequently their membranes are less likely to peroxidative damage. The relationship between maximum longevity and membrane peroxidation index is similar for these mice lines as previously observed for mammals in general. It is suggested that peroxidation-resistant membranes may be an important component of extended longevity.

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Citations

Oct 29, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Teresa G Valencak, Thomas Ruf
Jul 19, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Magdalene K MontgomeryWilliam A Buttemer
May 4, 2013·Age·Teresa G Valencak, Thomas Ruf
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A J HulbertRochelle Buffenstein
May 12, 2011·Integrative and Comparative Biology·A J Hulbert
May 13, 2011·The Journal of Experimental Biology·James M HarperRichard A Miller
Sep 10, 2011·PloS One·Magdalene K MontgomeryWilliam A Buttemer
Oct 17, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A J HulbertSarah K Abbott
Jul 19, 2012·Canadian Journal of Physiology and Pharmacology·Shaan E AlamPali Hungin
Sep 8, 2015·Experimental Gerontology·Samantha J AlperJames M Harper
Mar 20, 2014·Physiological and Biochemical Zoology : PBZ·Elisabeth A CalhoonJoseph B Williams
Jun 29, 2011·Free Radical Biology & Medicine·Piotr Zimniak
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Jul 22, 2009·Biochimica Et Biophysica Acta·Thomas Flatt, Paul S Schmidt
Jun 13, 2008·Ageing Research Reviews·Piotr Zimniak
Oct 21, 2015·Experimental Gerontology·Neda Nasiri MoghadamVolker Loeschcke
Aug 21, 2015·Chemistry and Physics of Lipids·Elisabeth A CalhoonJoseph B Williams
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Mar 21, 2016·Annals of the New York Academy of Sciences·R Scott McIsaacRochelle Buffenstein
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Feb 18, 2020·GeroScience·Nadine LenzhoferTeresa G Valencak
Jun 26, 2020·Frontiers in Physiology·Hannah ChewAlfred N Fonteh
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariona JovéReinald Pamplona
Jul 12, 2021·Molecular and Cellular Endocrinology·Lorna MulveyColin Selman

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