Extended low oxygen transmissibility contact lens use induces alterations in the concentration of proinflammatory cytokines, enzymes and electrolytes in tear fluid

Experimental and Therapeutic Medicine
Luis Fernando Barba GallardoJose Rafael Villafan Bernal

Abstract

Prolonged and continuous use of contact lenses for as long as 3 or 4 weeks is common in Mexico due to the low socioeconomic status, poor patient education and self-neglect. Furthermore, wearing contact lenses with low oxygen permeability is common due to their low cost. Thus, patients seek ophthalmologic evaluation due to signs and symptoms of overuse such as red eye, discomfort and tearing. In the present study, the effect of wearing soft contact lenses with a low oxygen permeability on the tear fluid composition after 1 day, 1 week and 1 month without removing them was examined. In this prospective clinical trial, several tear fluid biomarkers were measured in 84 non-adapted contact lens wearers (NACLWs), including the pH, electrolytes, osmolarity, pro-inflammatory molecules [interleukin (IL)-8, IL-1β and interferon (IFN)-γ], total protein (TP) levels and enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (AP)]. The results indicated that the tear pH was significantly decreased after 1 day and 1 week; however, after 1 month of use, the tear pH level returned to the baseline. Tear electrolyte analysis demonstrated a significant decrease in Na+ at 1 da...Continue Reading

References

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Jun 15, 2012·The British Journal of Ophthalmology·Javier González-PérezManuel Parafita
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Sep 10, 2013·Experimental Eye Research·Stephen C PflugfelderCintia S de Paiva

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Citations

Apr 10, 2019·Current Medicinal Chemistry·Alberto López-de la RosaAmalia Enríquez-de-Salamanca

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
GraphPad

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