Extended prediction rule to optimise early detection of heart failure in older persons with non-acute shortness of breath: a cross-sectional study

BMJ Open
Evelien E S van RietFrans H Rutten

Abstract

There is a need for a practical tool to aid general practitioners in early detection of heart failure in the elderly with shortness of breath. In this study, such a screening rule was developed based on an existing rule for detecting heart failure in older persons with a diagnosis of chronic obstructive pulmonary disease. The original rule included a history of ischaemic heart disease, body mass index, laterally displaced apex beat, heart rate, elevated N-terminal pro B-type natriuretic peptide and an abnormal ECG. Cross-sectional data were used to validate, update and extend the original prediction rule according to a standardised state-of-the-art stepwise approach. Primary care with 30 participating general practices. Community-dwelling people aged ≥ 65 years with shortness of breath on exertion. Validation of the existing screening rule in our population showed satisfying discrimination with a concordance statistic of 0.84 (range 0.80-0.85), but poor calibration. Performance measures were most improved by adding the predictors age >75 years, peripheral oedema and systolic murmur, resulting in a concordance statistic of 0.88 (range 0.85-0.90) and a net reclassification improvement of 31%. A risk score was computed, which show...Continue Reading

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Citations

Jul 10, 2016·Asian Pacific Journal of Tropical Medicine·Yin-Hao CaiMing-Yao You
Mar 12, 2019·ESC Heart Failure·Joe GallagherMark T Ledwidge
Sep 30, 2020·Journal of Clinical Medicine·Kazuto MatsunagaTsunahiko Hirano

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Methods Mentioned

BETA
coronary artery bypass

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R
SPSS

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