Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials

CNS Drugs
Richard H WeislerSPD417 Study Group

Abstract

Recently, two large, 3-week, randomised, double-blind, placebo-controlled trials using nearly identical protocols demonstrated that monotherapy with carbamazepine extended-release capsules (CBZ-ERC) was effective for the treatment of acute mania in patients with bipolar I disorder. By pooling data from these two trials, a more highly powered analysis of the efficacy and safety of CBZ-ERC in bipolar I disorder could be conducted. Efficacy was assessed with the Young Mania Rating Scale (YMRS), the Clinical Global Impression (CGI)-Severity (CGI-S) scale, the CGI-Improvement (CGI-I) scale and the Hamilton Depression Rating Scale (HDRS). A sub-analysis of the data based on manic versus mixed presentation was performed, as well as sub-analyses by age, sex and ethnicity. Of the 443 randomised patients in the pooled population, 240 completed the studies. Forty-two percent of CBZ-ERC-treated patients did not complete the studies, compared with 50% of placebo-treated patients (p=0.087). Ten percent of patients given CBZ-ERC withdrew because of lack of efficacy, compared with 22% of patients given placebo (p<0.001). At endpoint, CBZ-ERC compared with placebo was associated with significant improvements in mean YMRS total scores in patient...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jan 11, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·P E KeckC B Nemeroff
Jan 11, 1991·Archives of General Psychiatry·H G PopeJ I Hudson
Aug 8, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Jan 1, 1986·The American Journal of Psychiatry·R M PostR T Joffe
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Nov 1, 1996·Biological Psychiatry·S C DilsaverY Tsai
Nov 1, 1996·Psychopharmacology·R M PostM A Frye
Dec 31, 1997·The Journal of Clinical Psychiatry·K D DenicoffR M Post
Oct 21, 1999·International Clinical Psychopharmacology·W Greil, N Kleindienst
Oct 6, 2000·Biological Psychiatry·S L McElroy, P E Keck
Jan 31, 2002·Annual Review of Medicine·Philip B Mitchell, Gin S Malhi
Apr 2, 2003·The American Journal of Psychiatry·Paul E KeckUNKNOWN Ziprasidone in Mania Study Group
Aug 29, 2003·The American Journal of Psychiatry·Paul E KeckUNKNOWN Aripiprazole Study Group
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
May 19, 2004·Acta Neurologica Scandinavica·A D MillerF M Hamzeh
Jun 1, 2004·The American Journal of Psychiatry·Robert M A HirschfeldFred Grossman

❮ Previous
Next ❯

Citations

May 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisEduard Vieta
Oct 27, 2006·Development and Psychopathology·Melissa P DelBello, Robert A Kowatch
Feb 20, 2010·Journal of Child and Adolescent Psychopharmacology·Gagan JoshiJoseph Biederman
Mar 26, 2011·Annals of General Psychiatry·Konstantinos N FountoulakisZoltan Rihmer
Jun 21, 2013·Neuropsychiatric Disease and Treatment·Calvert G Warren, Steven L Dubovsky
Jan 23, 2009·Primary Care Companion to the Journal of Clinical Psychiatry
May 16, 2007·Journal of Clinical Psychopharmacology·Leslie CitromeDavid W Boulton
Dec 24, 2008·Expert Review of Neurotherapeutics·Leslie Citrome
Jun 16, 2006·Expert Opinion on Drug Safety·Matthew A FullerThomas D Gazda
Oct 27, 2006·Expert Opinion on Emerging Drugs·Philip B Mitchell, Gin S Malhi
Jan 30, 2007·Current Medical Research and Opinion·Terence A Ketter, Dan W Haupt
Dec 16, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Paul RubnerAndreas Conca
Feb 21, 2013·L'Encéphale·J-M Azorin
Feb 21, 2013·L'Encéphale·Pierre-Michel LlorcaLudovic Samalin
Oct 19, 2007·Acta Psychiatrica Scandinavica. Supplementum·G S Sachs, E E Gardner-Schuster
Dec 18, 2009·CNS Neuroscience & Therapeutics·A R RosaE Vieta
Apr 27, 2010·CNS Neuroscience & Therapeutics·Joseph BiedermanJanet Wozniak
Sep 16, 2015·CNS Drugs·Andrea FagioliniAllan H Young
Mar 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
May 16, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz Grunze, Jean Michel Azorin
Mar 8, 2011·Journal of Psychiatric Research·Mytilee VemuriNatalie L Rasgon
Jan 6, 2012·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisLakshmi N Yatham
May 23, 2007·Clinical EEG and Neuroscience·Benedikt AmannMichael Trimble
Apr 19, 2017·CNS Spectrums·Alessandro CuomoAllan H Young
Mar 31, 2009·Journal of Psychopharmacology·G M Goodwin, UNKNOWN Consensus Group of the British Association for Psychopharmacology
Jan 1, 2011·Journal of Central Nervous System Disease·Rif S El-MallakhR Jeannie Roberts
Nov 24, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Young Sup WooBo-Hyun Yoon
Feb 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Mauricio TohenWaldemar Greil
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Akshya VasudevAllan H Young
Nov 30, 2018·Expert Opinion on Pharmacotherapy·Monika BanachStanisław J Czuczwar
Nov 4, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN Members of the WFSBP Task Force on Bipolar Affective Disorders Working on this topic
Feb 12, 2017·Chonnam Medical Journal·Ather Muneer

❮ Previous
Next ❯

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