Extended-release formulations of antiepileptic drugs: rationale and comparative value.

Epilepsy Currents
Emilio Perucca

Abstract

Extended-release products are designed to prolong the absorption of drugs with short half-lives, thereby allowing longer dosing intervals while minimizing fluctuations in serum drug levels. The relationship between serum drug concentration and clinical effects of antiepileptic drugs (AEDs) can be complex and reducing fluctuations in serum drug levels is not equally advantageous for all AEDs. Extended-release formulations have been shown to be particularly valuable for carbamazepine, whereas for other AEDs advantages, other than prolongation of the dosing interval, have not been clearly demonstrated. Differences in bioavailability may exist between extended-release and immediate-release formulations and among different brands of extended-release products. Therefore, when switching from one formulation to another, careful monitoring of clinical response and attention to the need for dose adjustment are warranted.

References

Jan 1, 1991·Journal of Child Neurology·A Richens
Apr 1, 1980·Developmental Medicine and Child Neurology·A Covanis, P M Jeavons
Sep 14, 2001·European Journal of Drug Metabolism and Pharmacokinetics·M R FengT Su
Jul 18, 2002·Epilepsia·Matthew C WalkerDimitri M Kullmann
Mar 1, 2003·Epilepsy & Behavior : E&B·Joyce A. CramerVincent Rienzi
May 19, 2004·Acta Neurologica Scandinavica·A D MillerF M Hamzeh
Feb 8, 2005·Seizure : the Journal of the British Epilepsy Association·S ArroyoP M Crawford
Feb 9, 2005·Neurology·A BeydounUNKNOWN Pregabalin 1008-009 Study Group
Apr 24, 2007·Epilepsy Research·Dorothée G A Kasteleijn-Nolst TrenitéRenzo Guerrini
Sep 6, 2007·Neurology·D G A Kasteleijn-Nolst TrenitéE Hirsch
Oct 17, 2007·Neurology·D K NaritokuL Ríos Pohl
Dec 10, 2008·CNS Drugs·Mayur M PatelAvani F Amin
Aug 1, 1976·British Journal of Clinical Pharmacology·S I JohannessenP L Morselli

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Citations

Sep 16, 2014·Expert Review of Neurotherapeutics·Steve Chung
Nov 9, 2011·Advanced Drug Delivery Reviews·Cecilie Johannessen LandmarkTorbjörn Tomson
Apr 23, 2011·Lancet Neurology·Emilio Perucca, Torbjörn Tomson
Jul 1, 2011·Annals of Neurology·Gregory L KraussKelly Chuang
Nov 19, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Masoomeh Yosefifard, Majid Hassanpour-Ezatti
Jan 16, 2013·Pharmaceutical Development and Technology·Irina Kadiyala, Elijah Tan
Apr 20, 2018·Expert Opinion on Pharmacotherapy·Christian Brandt, Theodor W May
Apr 5, 2019·Expert Opinion on Drug Safety·Sameer Sharma, Patrick Kwan
Oct 19, 2019·Expert Review of Neurotherapeutics·Alessandra MoranoCarlo Di Bonaventura
Sep 6, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·James W Wheless, Stephanie J Phelps
Nov 30, 2018·Expert Opinion on Pharmacotherapy·Monika BanachStanisław J Czuczwar
Mar 8, 2016·The Mental Health Clinician·Marketa Marvanova
Dec 20, 2018·Epilepsia Open·Emilio Perucca
Dec 21, 2021·Bulletin of Mathematical Biology·Elijah D Counterman, Sean D Lawley

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