Extended-release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living with HIV and Alcohol use Disorders Transitioning to the Community: Results From a Double-Blind, Placebo-Controlled Trial

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Sandra A SpringerFrederick L Altice

Abstract

To determine whether extended-release naltrexone (XR-NTX) would improve or maintain viral suppression (VS) among incarcerated individuals with HIV and alcohol use disorders (AUDs) transitioning to the community. A randomized, double-blind, placebo-controlled trial was conducted among incarcerated individuals with HIV and AUDs transitioning to the community from 2010 through 2016. Eligible participants (N = 100) were randomized 2:1 to receive 6 monthly injections of XR-NTX (n = 67) or placebo (n = 33) starting at release and continued for 6 months. The primary and secondary outcomes were the proportion that maintained or improved VS at <200 and <50 copies per milliliter from baseline to 6 months, respectively, using an intention-to-treat analysis. Participants allocated to XR-NTX improved VS from baseline to 6 months for <200 copies per milliliter (48.0%-64.2%, P = 0.024) and for <50 copies per milliliter (31.0%-56.7%, P = 0.001), whereas the placebo group did not (<200 copies/mL: 64%-42.4%, P = 0.070; <50 copies/mL: 42.0%-30.3%, P = 0.292). XR-NTX participants were more likely to achieve VS than the placebo group at 6 months (<200 copies/mL: 64.2% vs. 42.4%; P = 0.041; <50 copies/mL: 56.7% vs. 30.3%; P = 0.015). XR-NTX independ...Continue Reading

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Citations

Jun 21, 2019·Current Opinion in HIV and AIDS·Anna P Deryabina, Wafaa M El-Sadr
Jul 26, 2019·Current Opinion in HIV and AIDS·Adeeba KamarulzamanFrederick L Altice
Aug 20, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David P SerotaSandra A Springer
Feb 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra A Springer, Carlos Del Rio
Aug 20, 2019·Current Opinion in HIV and AIDS·Jonathan A Colasanti, Wendy S Armstrong
Jan 27, 2019·Current HIV/AIDS Reports·Laura FanucchiP Todd Korthuis
Mar 20, 2020·Substance Abuse Treatment, Prevention, and Policy·Negin FarhadianMohsen Shahlaei
Apr 22, 2020·Current HIV/AIDS Reports·Natalie E ChichettoMatthew S Freiberg
Oct 30, 2019·Open Forum Infectious Diseases·Breanne E BiondiSandra A Springer
Dec 21, 2019·Journal of Substance Abuse Treatment·Benjamin J OldfieldKevin L Kraemer
Oct 21, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel M WoznicaChristopher J Hoffmann
Jun 24, 2020·Peptides·Richard J Bodnar
Mar 23, 2021·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Breanne E BiondiSandra A Springer
Nov 27, 2021·Alcoholism, Clinical and Experimental Research·Claire Slavin-StewartJames MacKillop

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