Extended Safety Data for the Oral Cavity Probiotic Streptococcus salivarius K12

Probiotics and Antimicrobial Proteins
Jeremy P BurtonJohn R Tagg

Abstract

Previous studies of the bacteriocin-producing Streptococcus salivarius K12 monitored a variety of intrinsic strain characteristics of potential relevance to its application as an oral probiotic in humans. These included the content of antibiotic resistance and virulence determinants, the production of deleterious metabolic by-products and its genetic stability. In the present study, we examined additional safety factors including the responses of rats to either short- or long-term oral dosing with strain K12 preparations. In addition, the potential genotoxicity of strain K12 was tested using a bacterial reverse mutation assay. To determine the occurrence and concentrations in human saliva of S. salivarius having the same bacteriocin phenotype as strain K12, saliva samples from 780 children were evaluated. The level of dosing with strain K12 required to achieve oral cavity colonization levels similar to those occurring naturally for this type of bacteriocin-producing S. salivarius was established using 100 human subjects. Following the oral instillation of lyophilized S. salivarius K12 cells in these subjects, its persistence was not at levels higher than those found naturally for this type of bacterium. The various sets of data...Continue Reading

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Citations

Dec 13, 2012·Future Microbiology·Philip A WescombeJohn R Tagg
Oct 31, 2012·Cellular and Molecular Life Sciences : CMLS·Riadh HammamiIsmail Fliss
Jul 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J P BurtonJ R Tagg
Aug 16, 2011·Beneficial Microbes·J P BurtonJ R Tagg
Dec 1, 2017·The Pediatric Infectious Disease Journal·Hélène DoyleJulian Crane
Nov 1, 2011·Journal of Bacteriology·Nicholas C K HengJohn R Tagg
Sep 27, 2019·Critical Reviews in Food Science and Nutrition·Jonathan C L ChuaPhil J Bremer
May 9, 2021·BMC Oral Health·Kyle W MacDonaldJeremy P Burton
May 13, 2021·International Journal of Clinical Pediatric Dentistry·Srihari Nirguna ChandrasekharHenna P Salim
May 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xuyao LiMizue Naito

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