Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia

Resuscitation
Anne L SolevågBritt Nakstad

Abstract

The rationale for a compression to ventilation ratio of 3:1 in neonates with primary hypoxic, hypercapnic cardiac arrest is to emphasize the importance of ventilation; however, there are no published studies testing this approach against alternative methods. An extended series of cardiac compressions offers the theoretical advantage of improving coronary perfusion pressures and hence, we aimed to explore the impact of compression cycles of two different durations. Newborn swine (n = 32, age 12-36 h, weight 2.0-2.7 kg) were progressively asphyxiated until asystole occurred. Animals were randomized to receive compressions:ventilations 3:1 (n=16) or 9:3 (n=16). Return of spontaneous circulation (ROSC) was defined as a heart rate ≥ 100 beats min⁻¹. All animals except one in the 9:3 group achieved ROSC. One animal in the 3:1 group suffered bradycardia at baseline, and was excluded, leaving us with 15 animals in each group surviving to completion of protocol. Time to ROSC (median and interquartile range) was 150 s (115-180) vs. 148 s (116-195) for 3:1 and 9:3, respectively (P = 0.74). There were no differences in diastolic blood pressure during compression cycles or in markers of hypoxia and inflammation. The temporal changes in mean...Continue Reading

Associated Clinical Trials

References

Dec 1, 1994·Circulation·N C ChandraS Permutt
Jan 1, 1993·Archives of Disease in Childhood·C Palme-KilanderY Chiwei
Sep 23, 2006·Resuscitation·Antonio Rodríguez-NúñezUNKNOWN Spanish Study Group for Cardiopulmonary Arrest in Children

❮ Previous
Next ❯

Citations

Aug 8, 2013·Seminars in Fetal & Neonatal Medicine·Lindsay F J Mildenhall, Trang K Huynh
Nov 21, 2012·Clinics in Perinatology·Vishal Kapadia, Myra H Wyckoff
Oct 20, 2015·Resuscitation·Koenraad G MonsieursUNKNOWN ERC Guidelines 2015 Writing Group
Aug 25, 2015·Resuscitation·Anne Lee SolevågGeorg Marcus Schmölzer
Apr 5, 2011·Acta Paediatrica·O D Saugstad, UNKNOWN International Liason Committee on Resuscitation
Apr 29, 2015·Maternal Health, Neonatology and Perinatology·Payam ValiSatyan Lakshminrusimha
Dec 3, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anne Lee SolevågGeorg M Schmölzer
Apr 26, 2017·PloS One·Payam ValiSatyan Lakshminrusimha
Jun 21, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Keso Skhirtladze-Dworschak, Martin Dworschak
Jul 1, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Payam ValiSatyan Lakshminrusimha
Feb 28, 2018·Frontiers in Pediatrics·Nariae BaikGeorg M Schmölzer
Feb 20, 2017·Journal of the American Heart Association·Payam ValiSatyan Lakshminrusimha
Jan 6, 2019·Children·Catalina Garcia-Hidalgo, Georg M Schmölzer
Dec 5, 2018·Minerva pediatrica·Megan O'reilly, Georg M Schmölzer
Apr 17, 2019·Children·Payam ValiSatyan Lakshminrusimha
May 28, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sparsh PatelGeorg M Schmölzer
May 17, 2017·Frontiers in Pediatrics·Vishal S Kapadia, Myra H Wyckoff
Apr 12, 2021·The American Journal of Emergency Medicine·Afrodite AggelinaNicoletta Iacovidou
May 27, 2021·Clinical and Experimental Emergency Medicine·Ju Sun HeoUNKNOWN Steering Committee of 2020 Korean Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Nov 16, 2021·Annals of the New York Academy of Sciences·Elise L Huppert, Sam Parnia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.