Extended Study of NUS1 Gene Variants in Parkinson's Disease

Frontiers in Neurology
Lamei YuanHao Deng

Abstract

Parkinson's disease (PD), is the second most common neurodegenerative disorder worldwide. Genetic, environmental factors, and aging are its primary development contributors. Recently the nuclear undecaprenyl pyrophosphate synthase 1 homolog (Saccharomyces cerevisiae) gene (NUS1) was reported as a candidate gene for PD, which raised our interest in the relationship between NUS1 and PD. This study was aimed to further explore the role of NUS1 variants in PD development. Genetic analysis for 308 Han-Chinese PD patients and 308 ethnically matched controls using whole exome sequencing was conducted. Additionally, a total of 60 articles involving in whole exome/whole genome sequencing or direct sequencing of the NUS1 gene from PubMed database between July 1, 2011 and August 26, 2020 were reviewed to evaluate PD-associated NUS1 variants. No potentially pathogenic NUS1 variant was found in 308 PD cases, and no frequency biases between 308 PD cases and 308 controls were observed for the only non-synonymous variant p.Asp179Glu (genotype: χ2 = 0.093, P = 0.761; allele: χ2 = 0.092, P = 0.762). No pathogenic or disease-associated NUS1 variant was reported in the 5,636 PD cases of the 60 articles. In summary, current findings indicate that N...Continue Reading

References

Jun 15, 2007·Expert Review of Neurotherapeutics·Michael R DouglasDavid J Nicholl
May 17, 2011·The EMBO Journal·Kenneth D HarrisonWilliam C Sessa
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Christine Klein, Ana Westenberger
Feb 8, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew B SingletonVincenzo Bonifati
Sep 3, 2014·JAMA Neurology·Joseph Jankovic, Todd Sherer
Feb 24, 2015·Trends in Genetics : TIG·Aline VerstraetenChristine Van Broeckhoven
Mar 12, 2015·Trends in Biochemical Sciences·Brent J RyanRichard Wade-Martins
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Dec 24, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Alastair J Noyce, Mike A Nalls
Oct 19, 2016·Lancet Neurology·Alberto Ascherio, Michael A Schwarzschild
Nov 30, 2016·Genome Biology·Rocio Acuna-HidalgoAlexander Hoischen
Feb 25, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto J EspayAnthony E Lang
Mar 12, 2017·Journal of Parkinson's Disease·Robert L Nussbaum
May 2, 2017·Progress in Neurobiology·Ana O PiresAntónio J Salgado
Jul 25, 2017·Current Neurology and Neuroscience Reports·Andreas Puschmann
Aug 10, 2017·Neuroscience Bulletin·Ronglin WangQian Yang
Nov 4, 2017·American Journal of Human Genetics·Fadi F HamdanJacques L Michaud
Dec 31, 2017·Ageing Research Reviews·Hao DengJoseph Jankovic
Mar 15, 2018·Cell and Tissue Research·K J BillingsleyA B Singleton
May 13, 2018·Neurology·Erik BootUNKNOWN International Research Group on 22q11.2DS-associated Parkinson's Disease
Jun 12, 2018·Lancet Neurology·Marialuisa QuadriUNKNOWN International Parkinsonism Genetics Network
Sep 27, 2018·Brain and Behavior·Lamei YuanHao Deng
Oct 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ji-Feng GuoBei-Sha Tang
Dec 12, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Joanne TrinhChristine Klein
May 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasSamuel M Goldman
Jun 19, 2019·Neuro-degenerative Diseases·Xiangyu ChenLamei Yuan
Oct 5, 2019·Neurobiology of Aging·Xiang ChenPingyi Xu
Jun 4, 2020·Journal of Neurology·Aristide MerolaAlberto J Espay

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Citations

Mar 19, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Seok-Ho YuRichard Steet

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Methods Mentioned

BETA
exome sequencing
Phenotyping
glycosylation

Software Mentioned

PROVEAN Protein Variation Effect Analyzer
SIFT
Polymorphism Phenotyping 2 ( PolyPhen - 2 )
PANTHER Protein Analysis Through Evolutionary Relationships
PROVEAN
SPSS
PolyPhen
Predictive Analytics Software Statistics
Protein Analysis Through Evolutionary Relationships ( PANTHER )
gnomAD

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