Extending far and wide: the role of biopsy and staging in the management of ocular surface squamous neoplasia

Clinical & Experimental Ophthalmology
Ashley PolskiJesse L Berry

Abstract

Although the most recent American Joint Committee on cancer staging guidelines for ocular surface squamous neoplasia place a heightened emphasis on biopsy and histopathologic analysis, the interpretation and clinical relevance of these staging criteria are not always clear. We address limitations of using histopathologic analysis to predict clinical outcomes and suggest less-invasive assessments. To investigate the impact of histopathologic depth of invasion on outcomes for tumours with the common presentation of multiple structure involvement. Retrospective chart review at tertiary institution. Of 41 eyes with ocular surface squamous neoplasia between 2012 and 2017, 27 tumours involving multiple ocular structures clinically were included. Biopsied tumours were determined to be invasive beyond the basement membrane or non-invasive; non-biopsied tumours were clinically identified with unknown depth of invasion. Outcomes were compared using Fisher's exact or Student's t tests. Proportion of tumours cured, recurred and/or persisting. Twelve tumours (44%) received primary excisional biopsy, 10 (37%) received chemotherapy without biopsy and 5 (19%) received chemotherapy and biopsy. Clinical diagnosis was correct in all biopsied case...Continue Reading

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Citations

Mar 21, 2019·Clinical & Experimental Ophthalmology·Max R ConwayAnthony M Joshua
Jul 18, 2020·The British Journal of Ophthalmology·Beatrice GalloMandeep S Sagoo
Jul 21, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gustavo SavinoMaria Antonietta Blasi

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