Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products

Trends in Immunology
S SivoriA Moretta

Abstract

Killer Ig-like receptors (KIRs) are human natural killer (NK) receptors that recognize allotypic determinants of human leukocyte antigen (HLA) class I. Inhibitory KIRs discriminate normal cells from tumour or virus-infected cells that have lost or reduced HLA class I expression. Donor NK cell "alloeffector" responses are exploited in haploidentical haematopoietic stem cell transplantation to treat leukaemia. NK cells also express several toll-like receptors (TLRs) that increase NK cell cytotoxicity and cytokine release in response to ligands. Surprisingly, KIR3DL2 binds the TLR ligand CpG-oligodexynucleotides, and together, they are co-internalized and translocated to TLR9-rich early endosomes. This novel KIR-associated function offers clues to understanding the NK cell response to microbial infection, and extends the role played by KIRs in immune defence.

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Citations

Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter ParhamLisbeth A Guethlein
Oct 25, 2013·Science Translational Medicine·Amir HorowitzCatherine A Blish
Mar 4, 2014·Seminars in Immunology·Mariella Della ChiesaAlessandro Moretta
May 11, 2011·FEBS Letters·Lorenzo MorettaAlessandro Moretta
Sep 6, 2011·Trends in Immunology·Paola VaccaMaria Cristina Mingari
May 8, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Elisa MontaldoLorenzo Moretta
Apr 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SternJ Villard
Mar 29, 2014·Frontiers in Immunology·Simona SivoriEmanuela Marcenaro
Mar 5, 2019·HLA : Immune Response Genetics·Michela FalcoLorenzo Moretta
Aug 18, 2020·Molecular Aspects of Medicine·Simona SivoriLorenzo Moretta
May 8, 2018·International Immunopharmacology·Kumar Vijay

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