Extension of peripheral nonperfusion in eyes with retinal vein occlusion during intravitreal dexamethasone treatment

Acta Ophthalmologica
Sandra Rezar-DreindlStefan Sacu

Abstract

To evaluate the change in peripheral perfusion status in patients with retinal vein occlusion (RVO) during dexamethasone treatment. Thirty-five eyes of patients with macular oedema due to either branch or central retinal vein occlusion were included. At baseline, patients were treated with an intravitreal dexamethasone implant (Ozurdex®) and followed until month 6. Wide-field angiographies were classified as ischaemic and nonischaemic. Peripheral nonperfusion (PNP) was determined manually by calculating the percentage of nonperfusion area in relation to the total visible retina (ischaemic index). Thirteen eyes showed evidence of >10 disc area of PNP at baseline and were graded as ischaemic RVO. In nonischaemic eyes, the mean area of PNP was 0.3% at baseline, 0.6% after 1 month, 0.6% after 3 months and 0.6% after 6 months, respectively (p > 0.05). In ischaemic RVO, the ischaemic index was calculated to be 18% at baseline. One month after treatment, mean area of PNP was 16% and after 3 months was 19% (p = 0.8; p = 0.6). After retreatment, total PNP area was 18% (month 6; p = 0.9). During treatment, best-corrected visual acuity (BCVA) increased and central retinal thickness (CRT) decreased from baseline to final follow-up with no ...Continue Reading

References

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Jul 15, 2000·Documenta Ophthalmologica. Advances in Ophthalmology·S A VinoresP A Campochiaro
Dec 9, 2008·Investigative Ophthalmology & Visual Science·Marion FunkUrsula Schmidt-Erfurth
Aug 13, 2010·Developments in Ophthalmology·Albert AugustinBaruch D Kuppermann
Jul 2, 2016·International Journal of Ophthalmology·Kaveh Abri AghdamFlorian Seidensticker

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