Extensive antigenic changes in an atypical isolate of very virulent infectious bursal disease virus and experimental clinical control of this virus with an antigenically classical live vaccine

Avian Pathology : Journal of the W.V.P.A
N EterradossiPierre-Marie Borne

Abstract

The 99323 Egyptian isolate of infectious bursal disease (IBD) virus (IBDV) was identified during an international survey of acute IBD cases. Its unique antigenicity was characterized by a markedly reduced binding of neutralizing monoclonal antibodies 3, 4, 5, 6, 8 and 9 in an antigen-capture enzyme-linked immunosorbent assay. Nucleotide sequencing of the genome region encoding the VP2 major immunogenic domain in 99323 revealed amino acid changes occurring at positions critical for antigenicity, but phylogenetic analysis demonstrated that 99323 was related to typical, very virulent IBDV (e.g. isolate 89163). Protection experimentally afforded by an antigenically classical live IBD vaccine was investigated in specific pathogen free chickens challenged with 99323 or 89163. Both viruses were similarly controlled, as evaluated by clinical signs, growth retardation, bursa-to-body weight ratios and histological lesions of the bursa after challenge. These results document that an active antibody response to a classical live antigen may clinically control infection by an antigenically atypical very virulent IBDV.

References

Nov 1, 1992·Veterinary Microbiology·H MüllerD H Lütticken
Nov 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·N EterradossiG Bennejean
Sep 2, 1989·The Veterinary Record·N ChettleP J Wyeth
Aug 1, 1993·The Journal of General Virology·D SchnitzlerH Becht
Feb 1, 1994·Virus Research·V N VakhariaD B Snyder
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·E Mundt, V N Vakharia
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·Mohamed K HassanMona M Aly
Mar 1, 1991·Avian Pathology : Journal of the W.V.P.A·T P BergG Meulemans
Jun 1, 2000·Avian Pathology : Journal of the W.V.P.A·T P Berg

❮ Previous
Next ❯

Citations

Sep 28, 2007·Avian Pathology : Journal of the W.V.P.A·Davor OjkicMarina Brash
Apr 21, 2012·Avian Pathology : Journal of the W.V.P.A·Hermann MüllerM Rafiqul Islam
Dec 28, 2012·Journal of Virology·Olivier EscaffreNicolas Eterradossi
Oct 12, 2012·Avian Diseases·Tamiru NegashSilke Rautenschlein
Dec 22, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kai LiNicolas Eterradossi
Oct 18, 2016·Avian Pathology : Journal of the W.V.P.A·Sébastien M SoubiesNicolas Eterradossi
Dec 20, 2005·The Journal of General Virology·Cyril Le NouënNicolas Eterradossi
Jan 8, 2021·Avian Pathology : Journal of the W.V.P.A·Mohammad Rafiqul IslamHermann Müller
Nov 5, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ahmed SamySébastien M Soubies

❮ Previous
Next ❯

Datasets Mentioned

BETA
AJ583500
AJ632141
DV86
UK661

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

Phylip
Clustal W

Related Concepts

Related Feeds