Extensive cutaneous chromomycosis: Efficacy of combined terbinafine and cryotherapy

Annales de dermatologie et de vénéréologie
Y ElkhachineM Elhaouri

Abstract

Chromomycosis is a chronic fungal skin infection, mainly affecting the limbs. It is responsible for severe morbidity and its treatment remains long and disappointing. Rarely described in Morocco, we report a new observation that has evolved very well under treatment combining terbinafine and cryotherapy over a short duration. A 56-year-old patient, immunocompetent, had a pustular and crusty placard on both forearms that had evolved for a year. Mycological examination showed fumagoid bodies and cutaneous biopsy showed epithelioid granulomas and giant cells without necrosis. The PCR confirmed a chromomycosis at Fonsecaea pedrosoi. HIV serology was negative. Treatment with terbinafine 250mg/d for 6months combined to cryotherapy resulted in complete remission with initial clinical improvement after only 3 weeks. Chromomycosis occurs increasingly in non-tropical areas. If diagnostic methods become more effective, management remains difficult and poorly codified. Terbinafine-cryotherapy combination would bring a lot of benefits with a little risk to bothpractitioner and patient. This combined treatment would constitute an excellent therapeutic alternative because of its efficiency, feasibility, low cost, method of administration and ...Continue Reading

Citations

Aug 13, 2021·PLoS Neglected Tropical Diseases·Daniel Wagner C L SantosArnaldo Lopes Colombo

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