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Extensive decoupling of metabolic genes in cancer

PLoS Computational Biology

May 1, 2015

Ed Reznik, Chris Sander

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Abstract

Tumorigenesis requires the re-organization of metabolism to support malignant proliferation. We examine how the altered metabolism of cancer cells is reflected in the rewiring of co-expression patterns among metabolic genes. Focusing on breast and clear-cell kidney tumors, we report the...read more

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  • Extensive decoupling of metabolic genes in cancer

    PLoS Computational Biology

    May 1, 2015

    Ed Reznik, Chris Sander

    PMID: 25961905

    DOI: 10.1371/journal.pcbi.1004176

    Abstract

    Tumorigenesis requires the re-organization of metabolism to support malignant proliferation. We examine how the altered metabolism of cancer cells is reflected in the rewiring of co-expression patterns among metabolic genes. Focusing on breast and clear-cell kidney tumors, we report the...read more

    17
    2
    60

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