journal cover

Extensive decoupling of metabolic genes in cancer

PLoS Computational Biology

May 12, 2015

Ed Reznik, Chris Sander

Abstract

Tumorigenesis requires the re-organization of metabolism to support malignant proliferation. We examine how the altered metabolism of cancer cells is reflected in the rewiring of co-expression patterns among metabolic genes. Focusing on breast and clear-cell kidney tumors, we report the...read more

Mentioned in this Paper

Metabolic Process, Cellular
ErbB-2 Receptor
Tumor Cells, Uncertain Whether Benign or Malignant
Transcription Cofactor Activity
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Lipogenesis
Cytochrome C Oxidase
Patterns
PLOD2 gene
17
2
57
Paper Details
References
  • References46
  • Citations7
12345
  • References46
  • Citations7
1

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Extensive decoupling of metabolic genes in cancer

PLoS Computational Biology

May 12, 2015

Ed Reznik, Chris Sander

PMID: 25961905

DOI: 10.1371/journal.pcbi.1004176

Abstract

Tumorigenesis requires the re-organization of metabolism to support malignant proliferation. We examine how the altered metabolism of cancer cells is reflected in the rewiring of co-expression patterns among metabolic genes. Focusing on breast and clear-cell kidney tumors, we report the...read more

Mentioned in this Paper

Metabolic Process, Cellular
ErbB-2 Receptor
Tumor Cells, Uncertain Whether Benign or Malignant
Transcription Cofactor Activity
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Lipogenesis
Cytochrome C Oxidase
Patterns
PLOD2 gene
17
2
57

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Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

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Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine

Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and MedicineNovember 17, 2011
Heba W Z KhellaGeorge M Yousef
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Paper Details
References
  • References46
  • Citations7
12345
  • References46
  • Citations7
1
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