PMID: 9525623Apr 3, 1998Paper

Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS

Journal of Virology
Q Wei, P N Fultz

Abstract

A chimpanzee (C-499) infected for more than 9 years with two subtype B isolates of human immunodeficiency virus type 1 (HIV-1), one (HIV-1(SF2)) that replicates poorly and one (HIV-1(LAV-1b)) that replicates efficiently in chimpanzees, died of AIDS 11 years after initial infection (F. J. Novembre et al., J. Virol. 71:4086-4091, 1997). Nucleotide sequence and phylogenetic analyses of the C2 to V5 region of env (C2-V5env) in proviral DNA from peripheral blood lymphocytes obtained 22 months before death revealed two distinct virus populations. One of these populations appeared to be a recombinant in env, having the V3 loop from HIV-1(SF2) and the V4-V5 region from HIV-1(LAV-1b); the other population had evolved from HIV-1(LAV-1b). In addition to C2-V5env, the entire p17gag and nef genes were sequenced; however, based on nucleotide sequences and phylogeny, whether the progenitor of the p17gag and nef genes was SF2 or LAV-1b could not be determined. Compared to the two original viruses, the divergence of all clones of C2-V5env ranged from 9.37 to 20.2%, that of p17gag ranged from 3.11 to 9.29%, and that of nef ranged from 4.02 to 7.9%. In contrast, compared to the maximum variation of 20.2% in C2-V5env for C-499, the maximum diversi...Continue Reading

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Citations

Oct 27, 1998·AIDS Research and Human Retroviruses·M GirardP N Fultz
Jan 31, 2002·AIDS·I D TattJ P Clewley
Mar 19, 2004·Sexually Transmitted Diseases·Jason T Blackard, Kenneth H Mayer
Jun 10, 2004·AIDS Research and Human Retroviruses·Ana MachucaIndira Hewlett
May 14, 2016·Journal of Neurovirology·Pejman Rahimian, Johnny J He
Apr 8, 2000·Journal of Biomedical Science·J G Mikkelsen, F S Pedersen
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason T BlackardKenneth H Mayer
Jun 5, 2007·Molecular Biology and Evolution·Louise V WainPaul M Sharp
Nov 13, 2008·AIDS Research and Human Retroviruses·Carlos Augusto YabarEberth Quijano
Oct 4, 2000·Reviews in Medical Virology·K L BarlowJ P Clewley
Dec 13, 2005·Sexual Health·Megan C SteainNitin K Saksena
Apr 1, 1999·The Journal of Infectious Diseases·P N FultzL Yue
Apr 18, 2003·AIDS·Rafael NájeraMichael M Thomson
Apr 20, 2004·AIDS·Patricia N Fultz
Jun 16, 2004·Nature Reviews. Microbiology·Lauren O Bakaletz
Jun 27, 2003·Human Immunology·Sunita S Balla-JhagjhoorsinghJonathan L Heeney
Apr 24, 2008·BMC Cell Biology·Pei-Hsun ChengAnthony W S Chan

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