Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force.

Immunogenetics
Gaby G M DoxiadisRonald E Bontrop

Abstract

The DR region of primate species is generally complex and displays diversity concerning the number and combination of distinct types of DRB genes present per region configuration. A highly variable short tandem repeat (STR) present in intron 2 of nearly all primate DRB genes can be utilized as a quick and accurate high through-put typing procedure. This approach resulted previously in the description of unique and haplotype-specific DRB-STR length patterns in humans, chimpanzees, and rhesus macaques. For the present study, a cohort of 230 cynomolgus monkeys, including self-sustaining breeding groups, has been examined. MtDNA analysis showed that most animals originated from the Indonesian islands, but some are derived from the mainland, south and north of the Isthmus of Kra. Haplotyping and subsequent sequencing resulted in the detection of 118 alleles, including 28 unreported ones. A total of 49 Mafa-DRB region configurations were detected, of which 28 have not yet been described. Humans and chimpanzees possess a low number of different DRB region configurations in concert with a high degree of allelic variation. In contrast, however, allelic heterogeneity within a given Mafa-DRB configuration is even less frequently observed ...Continue Reading

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Citations

May 27, 2011·BMC Evolutionary Biology·Jennifer L BollmerPatricia G Parker
Aug 2, 2011·Immunogenetics·Gaby G M DoxiadisRonald E Bontrop
May 11, 2011·Immunogenetics·Caroline S FernandezStephen J Kent
Aug 21, 2012·American Journal of Primatology·Wai LiXiaoning Wang
Feb 27, 2018·Immunogenetics·Marit K H van der WielR E Bontrop
Jun 9, 2012·IMA Fungus·Michaela Lackner, G Sybren de Hoog
Mar 1, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jesse BruijnesteijnRonald E Bontrop
Feb 17, 2021·BMC Ecology and Evolution·Jeffrine J Rovie-RyanMohd Tajuddin Abdullah

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

DNASTAR
[UNK]
MEGA
Lasergene
Genemapper
SeqMan
MacVector tm

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