Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster.

Genetics Research
Shilpa SwarupRobert R H Anholt

Abstract

Epistasis is an important feature of the genetic architecture of quantitative traits, but the dynamics of epistatic interactions in natural populations and the relationship between epistasis and pleiotropy remain poorly understood. Here, we studied the effects of epistatic modifiers that segregate in a wild-derived Drosophila melanogaster population on the mutational effects of P-element insertions in Semaphorin-5C (Sema-5c) and Calreticulin (Crc), pleiotropic genes that affect olfactory behaviour and startle behaviour and, in the case of Crc, sleep phenotypes. We introduced Canton-S B (CSB) third chromosomes with or without a P-element insertion at the Crc or Sema-5c locus in multiple wild-derived inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and assessed the effects of epistasis on the olfactory response to benzaldehyde and, for Crc, also on sleep. In each case, we found substantial epistasis and significant variation in the magnitude of epistasis. The predominant direction of epistatic effects was to suppress the mutant phenotype. These observations support a previous study on startle behaviour using the same D. melanogaster chromosome substitution lines, which concluded that suppressing epistasi...Continue Reading

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Citations

Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shilpa SwarupRobert R H Anholt
Sep 1, 2012·Annual Review of Genetics·Robert R H Anholt, Trudy F C Mackay
Jul 24, 2015·Current Opinion in Behavioral Sciences·Robert R H Anholt, Trudy F C Mackay
Dec 19, 2015·Genes, Brain, and Behavior·Xiaofang HeRobert R H Anholt
Oct 7, 2014·Trends in Genetics : TIG·Matthew B Taylor, Ian M Ehrenreich
Jul 16, 2016·Cell·Timothy B Sackton, Daniel L Hartl
Sep 7, 2016·Parasitology International·Kenner Morais FernandesGustavo Ferreira Martins
Oct 24, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert R H Anholt, Trudy F C Mackay
Aug 24, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Trudy F C Mackay, Wen Huang
Jul 12, 2018·G3 : Genes - Genomes - Genetics·Yazmin L Serrano NegronSusan T Harbison
Jan 8, 2020·Genetics·Robert R H AnholtSusan T Harbison

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