Extensive evaluation of the instrumentation laboratory IL test D-Dimer immunoturbidimetric assay on the ACL 9000 determines the D-Dimer cutoff value for reliable exclusion of venous thromboembolism

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
N CurtinL Coss

Abstract

The clinical diagnosis of venous thromboembolism (VTE), which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), is often difficult and requires a number of imaging tests plus clinical assessment. It is now accepted that pretest clinical probability of disease plus a sensitive, quantitative D-Dimer assay can be used to reliably exclude VTE. In design of diagnostic strategies for VTE it is recommended that the D-Dimer assay be evaluated for sensitivity and specificity in well-designed, blinded studies using a cohort of patients for whom the assay will ultimately be used. Therefore we evaluated the IL Test D-Dimer on the ACL 9000 automated coagulation analyzer for its sensitivity and specificity in the diagnosis of VTE. A total of 512 patients admitted to the emergency department of Providence Hospital with suspected VTE were included in the dataset. Our aim was to find the clinically meaningful IL Test D-Dimer cutoff value, which would give us 100% sensitivity and the highest possible specificity for exclusion of VTE. Patients were categorized clinically into low, medium, or high pretest probability and had computed tomographic and/or ventilation-perfusion scans for investigation of PE and ultrasound studies f...Continue Reading

References

May 28, 1977·Lancet·M J MantM G Grace
May 6, 1974·JAMA : the Journal of the American Medical Association·G J CaranasosL E Cluff
Dec 30, 1982·The New England Journal of Medicine·R HullP Ockelford
May 13, 1996·Archives of Internal Medicine·D M BeckerJ E Humphries
Dec 12, 1996·The New England Journal of Medicine·J S Ginsberg
Apr 6, 2001·Seminars in Thrombosis and Hemostasis·A Perrier, H Bounameaux
Nov 28, 2001·British Journal of Haematology·M J KovacsP S Wells
May 21, 2003·Annals of Internal Medicine·Shannon M BatesJeffrey S Ginsberg
Sep 26, 2003·The New England Journal of Medicine·Philip S WellsMichael J Kovacs
Oct 28, 2003·Clinical Chemistry·Michael D BrownJeffery A Kline
Dec 17, 2003·British Journal of Haematology·David M KeelingUNKNOWN Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Jun 17, 2004·Seminars in Vascular Medicine·H BounameauxP S Wells

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Citations

Nov 15, 2008·Blood·Soheir S AdamCharles S Greenberg
Oct 1, 2005·Journal of Thrombosis and Haemostasis : JTH·P MoerlooseJ Arnout
Mar 10, 2005·British Journal of Haematology·Chris GardinerIan J Mackie
Nov 26, 2016·Phlebology·Marina KafezaAlun H Davies
Jan 8, 2009·The Korean journal of laboratory medicine·Rojin ParkYang-Ki Kim
Sep 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ainslie JohnstoneCharlotte J Stagg
Jul 8, 2015·Neurorehabilitation and Neural Repair·William HuynhMatthew C Kiernan
Oct 26, 2006·Critical Care Nursing Quarterly·Gail MarchigianoCarol Jo Morse

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