Extensive ganglioneuromatosis of gallbladder

International Journal of Surgical Pathology
Takahiko SakumaKiyoshi Kawano


A case of extensive ganglioneuromatosis (GN) of gallbladder is presented. A 38-year-old man presented with a hepatic hilar mass (Ø ~ 48 mm) and gall stones. He had undergone total thyroidectomy for medullary thyroid carcinoma 8 years earlier. The hepatic hilus tumor, which had been clinically suspected to be a lymph node metastasis from the medullary thyroid carcinoma, was found to be pheochromocytoma. The gallbladder, resected with a clinical diagnosis of cholelithiasis, showed extensive transmural GN despite a grossly normal appearance. Taking into account the past history, the patient was diagnosed as having multiple endocrine neoplasia 2b (MEN2b)-associated GN of gallbladder and ectopic pheochromocytoma. As GN of gallbladder in MEN2b has been rarely reported, the histological findings are described in detail and a brief review of literature is carried out.


Jan 13, 2005·The American Journal of Surgical Pathology·J Aidan Carney
Mar 30, 2005·Archives of Pathology & Laboratory Medicine·Shveta Mehra, Moonja Chung-Park

❮ Previous
Next ❯


Dec 3, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert Bruce MacIntoshMichael Lee
Aug 29, 2012·Journal of Comparative Pathology·J K ParisS H Smith
Feb 9, 2018·Journal of Clinical Pathology·Aoife J McCarthyRunjan Chetty
Jul 24, 2020·Clinical Endocrinology·Stephanie M J FliednerHendrik Lehnert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.