Extensive genetic diversity among populations of the malaria mosquito Anopheles moucheti revealed by population genomics

BioRxiv : the Preprint Server for Biology
Caroline FouetBradley J White

Abstract

Malaria vectors are exposed to intense selective pressures due to large-scale intervention programs that are underway in most African countries. One of the current priorities is therefore to clearly assess the adaptive potential of Anopheline populations, which is critical to understand and anticipate the response mosquitoes can elicit against such adaptive challenges. The development of genomic resources that will empower robust examinations of evolutionary changes in all vectors including currently understudied species is an inevitable step toward this goal. Here we constructed double-digest Restriction Associated DNA (ddRAD) libraries and generated 6461 Single Nucleotide Polymorphisms (SNPs) that we used to explore the population structure and demographic history of wild-caught Anopheles moucheti from Cameroon. The genome-wide distribution of allelic frequencies among samples best fitted that of an old population at equilibrium, characterized by a weak genetic structure and extensive genetic diversity, presumably due to a large long term effective population size. Estimates of FST and Linkage Disequilibrium (LD) across SNPs reveal a very low genetic differentiation throughout the genome and the absence of segregating LD bloc...Continue Reading

Related Concepts

Alleles
Disease Vectors
DNA
Genetic Vectors
Genome
Malaria
Culicidae
DNA, Double-Stranded
Anopheles moucheti
Adaptation

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