Extensive Mitochondrial Heteroplasmy in Natural Populations of a Resurging Human Pest, the Bed Bug (Hemiptera: Cimicidae)

Journal of Medical Entomology
G A RobisonWarren Booth

Abstract

Homoplasmy, the occurrence of a single mitochondrial DNA haplotype within an individual, has been the accepted condition across most organisms in the animal kingdom. In recent years, a number of exceptions to this rule have been reported, largely due to the ease with which single nucleotide polymorphisms can be detected. Evidence of heteroplasmy-two or more mitochondrial variants within a single individual-has now been documented in a number of invertebrates; however, when present, heteroplasmy usually occurs at low frequencies both within individuals and within populations. The implications of heteroplasmy may be far reaching, both to the individual in relation to its health and fitness, and when considering the evolutionary dynamics of populations. We present novel evidence for frequent mtDNA heteroplasmy in the bed bug, Cimex lectularius L. (Hemiptera: Cimicidae). Our findings show that heteroplasmy is common, with 5 of 29 (17%) populations screened exhibiting two mitochondrial variants in a ∼1:2 ratio within each individual. We hypothesize that the mechanism underlying heteroplasmy in bed bugs is paternal leakage because some haplotypes were shared among unrelated populations and no evidence for nuclear mitochondrial DNA se...Continue Reading

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Citations

Jul 5, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mohammad AkhoundiPascal Delaunay
Sep 13, 2016·Mitochondrial DNA. Part B, Resources·Sergios-Orestis KolokotronisRob DeSalle
Jan 10, 2020·Parasitology Research·Irina MuntaabskiAlejandra C Scannapieco
Feb 2, 2018·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Rubi N Meza-LázaroAlejandro Zaldívar-Riverón
Feb 8, 2019·Scientific Reports·Valentina MastrantonioSandra Urbanelli
Feb 9, 2021·Genome Biology and Evolution·Mariangela IannelloLiliana Milani
Jul 3, 2021·Life·Maria-Eleni Parakatselaki, Emmanuel D Ladoukakis

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