Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats.

BMC Neuroscience
Anna M S Kindlundh-HögbergHelgi B Schiöth

Abstract

Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA). Less attention has been given to the major excitatory neurotransmitter glutamate known to be implicated in schizophrenia and drug addiction. The aim of the present study was to investigate the effect of repeated intermittent MDMA administration upon gene-transcript expression of the glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), the glutamate receptor subunits of AMPA (GluR1, GluR2, GluR3), the glutamate receptor subunits of NMDA (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) in six different brain regions. Adolescent male Sprague Dawley rats received MDMA at the doses of 3 x 1 and 3 x 5 mg/kg/day, or 3x vehicle 3 hours apart, every 7th day for 4 weeks. The gene-transcript levels were assessed using real-time PCR validated with a range of housekeeping genes. The findings showed pronounced enhancements in gene-transcript expression of GluR2, mGluR1, mGluR5, NR1, NR2A, NR2B, EAAT1, and EAAT2-2 in the cortex at bregma +1.6. In the caudate putamen, mRNA levels of GluR3, NR2A, and NR2B receptor subunits w...Continue Reading

References

Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Mar 1, 1995·Brain Research. Molecular Brain Research·P Follesa, M K Ticku
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·F E PontieriG Di Chiara
Nov 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·R S Cohen
Jan 1, 1997·Journal of Neural Transmission·S Koch, M P Galloway
Jan 28, 1998·Critical Reviews in Neurobiology·C A Tamminga
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Jul 23, 1999·Annals of the New York Academy of Sciences·G Di ChiaraE Carboni
Dec 1, 1999·Biological Psychiatry·A CarlssonM L Carlsson
Jun 29, 2000·Neurochemistry International·P R DoddP A Wilce
Dec 20, 2000·Brain Research·L W Swanson
Dec 26, 2001·Brain Research. Brain Research Reviews·G D PetrovichL W Swanson
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Apr 2, 2003·Pharmacology & Therapeutics·J C Cole, H R Sumnall
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Apr 17, 2004·Psychopharmacology·K McCardleC Stough
May 14, 2004·Nature·Erika Check
Jun 24, 2004·Brain Research. Brain Research Reviews·Yasushi ShigeriKeiko Shimamoto
Sep 17, 2004·Psychopharmacology·Jörg DaumannEuphrosyne Gouzoulis-Mayfrank
May 17, 2005·Drug and Alcohol Dependence·Euphrosyne Gouzoulis-MayfrankJoerg Daumann

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Citations

Jun 23, 2009·Cellular and Molecular Neurobiology·Anna M S Kindlundh-HögbergAsa Fex Svenningsen
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Jun 9, 2009·Genes, Brain, and Behavior·O LevranM J Kreek
Sep 29, 2011·Genes, Brain, and Behavior·N Fernàndez-CastilloB Cormand
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Donna Seger
Nov 28, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marzieh GhaderiMohammad-Reza Zarrindast
Jan 8, 2013·Behavioural Brain Research·Luke K SherrillJoshua M Gulley
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Susan Schenk
Jan 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni HernandezPierre-Paul Rompré
Jan 21, 2014·Neuropharmacology·Joana GonçalvesAna Paula Silva
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Linda Patia Spear
Jun 13, 2017·The International Journal of Neuropsychopharmacology·Sade Spencer, Peter W Kalivas
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi

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Methods Mentioned

BETA
PCR

Software Mentioned

LinReg
Basic Local Alignment Search Tool ( BLAST )
Beacon Designer
iCycler
Statview
GeNorm

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