PMID: 9191074Jun 1, 1997Paper

Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors

Brain Research. Molecular Brain Research
G C MiescherA J Steck

Abstract

EHK-1 is a neuronal ELK-related receptor tyrosine kinase which interacts with multiple, membrane-anchored ligands. Recent experiments have suggested a role for some of these ligands in the formation of neuronal pathways. Here, we report the isolation of human EHK-1 cDNAs and the localization of the human EHK-1 gene to chromosome 4q12. Six EHK-1 mRNA splice variants encoding cell-surface receptors with catalytic domains were identified in adult human brain where a 120-kDa EHK-1 protein predominates. Immunohistochemistry for EHK-1 reveals a dendritic staining pattern in cortical neurons and cerebellar Purkinje cells and a marked accumulation of EHK-1 in the somas of pyramidal neurons within the cortex and hippocampus. Interestingly, we have identified lineage aberrant expression of EHK-1 in a number of human gliomas. In addition to functions during development, EHK-1 may be involved in the maintenance of the adult nervous system and contribute to glioma development.

References

Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T RiedD C Ward
Apr 7, 1994·Nature·T D BartleyB A Guthrie
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J D Inglis, M Lee
Oct 1, 1995·Journal of Neuroscience Research·M K CarpenterF A Fletcher

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Citations

May 12, 1998·Pharmacology & Therapeutics·R Zhou
Aug 23, 2011·Neuro-oncology·Mitsutoshi NakadaJun-ichiro Hamada
Sep 21, 2002·Microscopy Research and Technique·Masaru Nakamoto, Andrew D Bergemann
Jun 22, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G Olivieri, G C Miescher
Jan 30, 2009·Cancer Research·Nava AlmogAmir Abdollahi

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