Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis

G3 : Genes - Genomes - Genetics
Eugenia C OlesnickyElizabeth R Gavis

Abstract

The large number of RNA-binding proteins and translation factors encoded in the Drosophila and other metazoan genomes predicts widespread use of post-transcriptional regulation in cellular and developmental processes. Previous studies identified roles for several RNA-binding proteins in dendrite branching morphogenesis of Drosophila larval sensory neurons. To determine the larger contribution of post-transcriptional gene regulation to neuronal morphogenesis, we conducted an RNA interference screen to identify additional Drosophila proteins annotated as either RNA-binding proteins or translation factors that function in producing the complex dendritic trees of larval class IV dendritic arborization neurons. We identified 88 genes encoding such proteins whose knockdown resulted in aberrant dendritic morphology, including alterations in dendritic branch number, branch length, field size, and patterning of the dendritic tree. In particular, splicing and translation initiation factors were associated with distinct and characteristic phenotypes, suggesting that different morphogenetic events are best controlled at specific steps in post-transcriptional messenger RNA metabolism. Many of the factors identified in the screen have been i...Continue Reading

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Citations

Aug 15, 2015·Development Genes and Evolution·Logan T SchachtnerEugenia C Olesnicky
May 26, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eugenia C OlesnickyMeghan C Lybecker
Feb 13, 2015·G3 : Genes - Genomes - Genetics·Simona AntonacciDarrell J Killian
Jul 20, 2017·Genesis : the Journal of Genetics and Development·Bipin K TripathiMousumi Mutsuddi
Mar 23, 2019·Frontiers in Genetics·Sarah C Hughes, Andrew J Simmonds
Jun 5, 2016·G3 : Genes - Genomes - Genetics·Mala MisraElizabeth R Gavis
Mar 3, 2020·Frontiers in Molecular Biosciences·Bharti NawalpuriRavi S Muddashetty
Oct 6, 2020·Frontiers in Cellular Neuroscience·Erin N Lottes, Daniel N Cox
Aug 22, 2018·Journal of Developmental Biology·Eugenia C Olesnicky, Ethan G Wright
Oct 9, 2020·G3 : Genes - Genomes - Genetics·Wan SongW Daniel Tracey
Oct 24, 2018·Developmental Biology·Eugenia C OlesnickyDarrell J Killian

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Methods Mentioned

BETA
Transgenic
electron microscopy

Software Mentioned

modENCODE
FlyAtlas
NeuronJ

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