Oct 19, 2013

Extensive variation in chromatin states across humans

Science
Maya KasowskiMichael Snyder

Abstract

The majority of disease-associated variants lie outside protein-coding regions, suggesting a link between variation in regulatory regions and disease predisposition. We studied differences in chromatin states using five histone modifications, cohesin, and CTCF in lymphoblastoid lines from 19 individuals of diverse ancestry. We found extensive signal variation in regulatory regions, which often switch between active and repressed states across individuals. Enhancer activity is particularly diverse among individuals, whereas gene expression remains relatively stable. Chromatin variability shows genetic inheritance in trios, correlates with genetic variation and population divergence, and is associated with disruptions of transcription factor binding motifs. Overall, our results provide insights into chromatin variation among humans.

  • References40
  • Citations139

Citations

Mentioned in this Paper

Chromosomal Proteins, Non-Histone
Cell Cycle Proteins
Cohesins
CCCTC-binding factor
Gene Expression
Genetic Inheritance
Repressor Molecules
Transcription Factor Binding
Histone Modification
Chromatin Location

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