Extent and prevalence of spin in randomized controlled trials in dentistry.

Journal of Dentistry
Iro EleftheriadiNikolaos Pandis

Abstract

Spin, the misinterpretation of non-significant study results, can lead to erroneous conclusions about the effectiveness of interventions. It was the aim of this study to examine the presence and prevalence of spin in the dental literature and to identify potential associations with trials' characteristics. PubMed was searched for randomized controlled trials (RCTs) published between February 12,018 and January 31, 2019. Two reviewers screened the selected articles and evaluated them for spin using a standardized data collection form. Data on the selected RCTs and spin strategy, if present, were recorded for each study. Descriptive statistics and frequencies of various types of spin in the abstract and the main text were calculated and associations between spin and study characteristics were examined. Forty-seven RCTs were included in the final sample. Over 60 % of the articles presented some form of spin and 19.1 % presented more than one types of spin in the abstract. More than one types of spin were detected in more than half of the studies evaluated (53.2 %), whereas 78.7 % of the studies screened presented some type of spin in the main text. No statistically significant associations were found between any of the study chara...Continue Reading

References

Mar 27, 2002·International Journal of Epidemiology·Karen A Robinson, Kay Dickersin
Jun 28, 2003·BMJ : British Medical Journal·Ted J Kaptchuk
May 27, 2010·JAMA : the Journal of the American Medical Association·Isabelle BoutronDouglas G Altman
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Kerry DwanPaula R Williamson
Mar 9, 2011·International Dental Journal·Iacopo Cioffi, Mauro Farella
Oct 5, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Nikolaos Pandis
Oct 25, 2011·International Journal of Surgery·Kenneth F SchulzUNKNOWN CONSORT Group
Aug 21, 2012·Statistics in Medicine·Douglas G AltmanKenneth F Schulz
Jan 15, 2014·Lancet·Paul GlasziouElizabeth Wager
Jun 11, 2014·The Journal of Evidence-based Dental Practice·Evangelia LempesiNikolaos Pandis
Nov 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle BoutronPhilippe Ravaud
Oct 16, 2015·BMC Medical Research Methodology·Clément LazarusIsabelle Boutron
May 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Francisco E Vera-BadilloIan F Tannock
Nov 9, 2016·Annals of Translational Medicine·Padhraig S Fleming
Jan 10, 2018·Journal of General Internal Medicine·Alexandra WoodbridgeSalomeh Keyhani
Feb 16, 2018·Journal of Oral Rehabilitation·M Lira-OetikerS E Uribe
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Isabelle Boutron, Philippe Ravaud
Aug 25, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Dafne Port NascimentoLeonardo Oliveira Pena Costa
Nov 22, 2019·The Journal of the American Dental Association·Jordan I RoszhartSatheesh Elangovan

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Citations

Apr 20, 2021·International Endodontic Journal·G N Tzanetakis, D Koletsi

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