Extent and reasons for nonadherence to antihypertensive, cholesterol, and diabetes medications: the association with depressive symptom burden in a sample of American veterans

Patient Preference and Adherence
Hollis J WeidenbacherCorrine I Voils

Abstract

Persons with depressive symptoms generally have higher rates of medication nonadherence than persons without depressive symptoms. However, little is known about whether this association differs by comorbid medical condition or whether reasons for nonadherence differ by depressive symptoms or comorbid medical condition. Self-reported extent of nonadherence, reasons for nonadherence, and depressive symptoms among 1,026 veterans prescribed medications for hypertension, dyslipidemia, and/or type 2 diabetes were assessed. In multivariable logistic regression adjusted for clinical and demographic factors, the odds of nonadherence were higher among participants with high depressive symptom burden for dyslipidemia (n=848; odds ratio [OR]: 1.42, P=0.03) but not hypertension (n=916; OR: 1.24, P=0.15), or type 2 diabetes (n=447; OR: 1.15, P=0.51). Among participants reporting nonadherence to antihypertensive and antilipemic medications, those with greater depressive symptom burden had greater odds of endorsing medication nonadherence reasons related to negative expectations and excessive economic burden. Neither extent of nonadherence nor reasons for nonadherence differed by depressive symptom burden among patients with diabetes. These fi...Continue Reading

Citations

Jul 28, 2016·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Jennifer J SalinasLouis D Brown
May 1, 2019·Digestive Diseases and Sciences·Corrine I VoilsZiad F Gellad
Dec 19, 2018·American Journal of Pharmaceutical Education·Patricia L Darbishire, Daraoun Mashrah
Mar 5, 2020·Obesity Science & Practice·Elizabeth M VaughanUNKNOWN Look AHEAD Research Group
Jun 23, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Kyriakos SouliotisEvangelos Liberopoulos

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