Extent of atherosclerosis after 11-year prospective follow-up in patients with early rheumatoid arthritis was affected by disease severity at diagnosis

Scandinavian Journal of Rheumatology
I BjörseniusA Södergren

Abstract

Objective: Cardiovascular disease (CVD) is increased among patients with rheumatoid arthritis (RA). The underlying cause is not clear. In this prospective study, patients with early RA were investigated for associations between subclinical atherosclerosis and CVD risk factors as well as inflammation. Method: At diagnosis, RA patients were recruited into a prospective study. A subgroup was included (n = 55) for ultrasound measurements of intima-media thickness (IMT) at inclusion (T0), and after 5 years (T5) and 11 years (T11). Thirty-one age and gender-matched controls were also included for comparison. Results: IMT increased significantly between T0 and T11 among patients and controls (p < 0.0001). No statistically significant differences in IMT between patients and controls were detected at T11, T5, or T0 (p > 0.05 for all). In simple regression models, IMT at T11 was significantly associated with age (p < 0.0001), as well as systolic blood pressure at T0 (p < 0.01) and T11 (p < 0.01) among RA patients. Furthermore, the composite Systematic COronary Risk Evaluation (SCORE) measurements (p < 0.0001) and Reynolds risk score (p < 0.01) and the radiographic Larsen score (p < 0.05) at T0 were all significantly associated with IMT a...Continue Reading

References

Jun 6, 2003·European Heart Journal·R M ConroyUNKNOWN SCORE project group
Oct 29, 2005·Arthritis and Rheumatism·Inmaculada del RincónAgustín Escalante
Feb 15, 2007·JAMA : the Journal of the American Medical Association·Paul M RidkerNancy R Cook
Mar 14, 2008·Seminars in Arthritis and Rheumatism·Carlos Gonzalez-JuanateyMiguel A Gonzalez-Gay
Jun 21, 2008·Foodborne Pathogens and Disease·Michael BucherMaria Fredriksson-Ahomaa
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Jun 15, 2010·European Heart Journal·Daniel H O'Leary, Michiel L Bots
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Alper M van SijlMichael T Nurmohamed
Dec 15, 2010·Annals of the Rheumatic Diseases·Henrik KällbergUNKNOWN EIRA Study Group
Feb 10, 2011·Arthritis and Rheumatism·Matthew R EvansInmaculada del Rincón
Nov 3, 2011·The Journal of Rheumatology·Virginia Ruiz-EsquideRaimon Sanmartí
Mar 20, 2012·Annals of the Rheumatic Diseases·Juan Antonio Avina-ZubietaDiane Lacaille
Feb 27, 2015·Thrombosis and Haemostasis·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
Mar 25, 2017·Rheumatology·Cynthia S CrowsonUNKNOWN Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis
Jul 10, 2017·Bone·Michael A FueryEmile R Mohler
Oct 5, 2018·JAMA : the Journal of the American Medical Association·Daniel Aletaha, Josef S Smolen

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