Extent of Dorsolateral Prefrontal Cortex Plasticity and Its Association With Working Memory in Patients With Alzheimer Disease

JAMA Psychiatry
Sanjeev KumarTarek K Rajji

Abstract

The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer disease (AD) and its association with working memory are not known. To determine whether participants with AD had impaired DLPFC plasticity compared with healthy control participants, to compare working memory between participants with AD and controls, and to determine whether DLPFC plasticity was associated with working memory. This cross-sectional study included 32 participants with AD who were 65 years or older and met diagnostic criteria for dementia due to probable AD with a score of at least 17 on the Mini-Mental State Examination and 16 age-matched control participants. Participants were recruited from a university teaching hospital from May 2013 to October 2016. Plasticity of the DLPFC measured as potentiation of cortical-evoked activity using paired associative stimulation (a combination of peripheral nerve electrical stimulation and transcranial magnetic stimulation) combined with electroencephalography. Working memory was assessed with the n-back task (1- and 2-back) and measured using the A' statistic. Among the 32 participants with AD, 17 were women and 15 were men (mean [SD] age, 76.3 [6.3] years); among the 16 controls, 8 were men and 8 ...Continue Reading

Associated Clinical Trials

Citations

May 10, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer I LissemoreDaniel M Blumberger
Jul 31, 2019·Journal of the International Neuropsychological Society : JINS·Brian C KavanaughLinda L Carpenter
Sep 27, 2019·International Psychogeriatrics·Everton BalduinoJuliana Francisca Cecato
May 10, 2018·Frontiers in Human Neuroscience·Bahar SalavatiTarek K Rajji
Oct 24, 2018·Expert Review of Neurotherapeutics·Alesha HeathM Windy McNerney
Apr 10, 2020·Frontiers in Human Neuroscience·Karuna SubramaniamSrikantan S Nagarajan
Jun 19, 2018·Frontiers in Psychiatry·Chun-Hung ChangChieh-Hsin Lin
Sep 20, 2018·Alzheimer's Research & Therapy·Alberto BenussiBarbara Borroni
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Guoping FengJohn H Morrison
Dec 31, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Jordan LamDarrin J Lee
Jan 21, 2021·Stroke; a Journal of Cerebral Circulation·Russell P SawyerDaniel Woo
Feb 10, 2021·Neuropharmacology·Marc R PlagenhoefAlvin V Terry
Oct 2, 2020·Brain Stimulation·Chiara BagattiniCarlo Alberto Defanti
Feb 23, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adam MederUlf Ziemann
Mar 13, 2021·Ageing Research Reviews·Milan StoiljkovicMihály Hajós
Jun 9, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sanjeev Kumar
Sep 10, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Shaylyn JosephSanjeev Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Tarek K RajjiZafiris J Daskalakis
Journal of Neurology, Neurosurgery, and Psychiatry
M CotelliCarlo Miniussi
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
B R Mull, M Seyal
© 2022 Meta ULC. All rights reserved