Extent of hepatectomy on splenic hypertrophy and platelet count in live liver donors

Clinical Transplantation
Takeaki IshizawaMasatoshi Makuuchi

Abstract

The extent of donor hepatectomy may affect splenic hypertrophy and platelet count. The subjects were 50 live liver donors. The ratio of the graft weight to total liver volume (GW/TLV) and the splenic hypertrophy ratio, expressed as the splenic volume one month after surgery divided by that before surgery, were calculated. The platelet count one month after surgery was divided by that before surgery to determine the rate of the platelet count decrease. The correlation of GW/TLV to the splenic hypertrophy ratio and the rate of the platelet count decrease were examined. The median (range) GW/TLV was 54 (28-71)%. The splenic hypertrophy ratio and the rate of the platelet count decrease was 133 (99-191)% and 92 (71-129)%, respectively. GW/TLV positively correlated with the splenic hypertrophy ratio (Spearman's correlation coefficient (r(s)) = 0.448, p = 0.001), and negatively correlated with the rate of the platelet count decrease (r(s) = -0.471, p < 0.001). Multivariate analysis revealed that GW/TLV influenced the splenic hypertrophy ratio [adjusted odds ratio (OR), 12.0; 95% confidence interval (CI), 1.32-9.04; p = 0.01] and the ratio of the platelet count decrease (adjusted OR, 11.6; 95% CI, 1.40-8.33; p = 0.01). Larger graft pro...Continue Reading

References

Jan 1, 1992·The British Journal of Surgery·B SucF Fékété
Oct 1, 1980·The Journal of Surgical Research·A C ChartersJ P Froehlich
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yasuhiko SugawaraTakao Ohkubo
Feb 20, 2003·Transplantation Proceedings·T Y ChenY F Cheng
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roman SchumannDaniel B Carr
Sep 7, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Antonio SiniscalchiAlberto Pasetto
Oct 22, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Dianne Lapointe RudowMilan Kinkhabwala
Dec 2, 2004·World Journal of Surgery·Hideya AndoYuji Nimura
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Yan-Shen ShanPin-Wen Lin

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Citations

Dec 17, 2009·World Journal of Surgery·Fumio ChikamoriAndreas G Tzakis
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gheorghe PetrovaiFrançois-René Pruvot
May 23, 2012·Clinical Radiology·K E JacobsG Gayer
Aug 4, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mary Ann Simpson, Elizabeth A Pomfret
Mar 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Michael Millis
Mar 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James F TrotterUNKNOWN Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group
Dec 10, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jean C EmondRobert M Merion
Dec 20, 2014·The British Journal of Surgery·Y OnoA Saiura
Apr 22, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kenji YoshinoShinji Uemoto
Jun 9, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Abdullah KisaogluBulent Aydinli

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