Abstract
The aim of this study was to determine whether the extent of late gadolinium enhancement (LGE) is associated with left ventricular (LV) function in patients with hypertrophic cardiomyopathy (HCM). Forty-seven patients with HCM (35 males, mean age 53+/-14, 14 with LV outflow tract obstruction) underwent cardiovascular magnetic resonance imaging and comprehensive echocardiographic examination. The extent of LGE was expressed as LGE volume and LGE percentage of LV volume. LGE was present in 40 (85.1%) of 47 patients. The mean LGE volume was 36.5+/-36 cm3, and the mean percentage of LV volume was 16.4+/-17%. Following adjustment for age, mitral regurgitation and LV mass index, LGE volume and percentage positively correlated with the left atrial volume index (r=0.388, p=0.009 and r=0.425, p=0.004, respectively). However, there was no significant association of functional class, ejection fraction, mitral flow, or annular velocities with the extent of LGE. In HCM patients, the extent of LGE positively correlated with the left atrial volume index, a surrogate marker of chronic diastolic burden. These findings suggest that myocardial scarring may be a pathologic substrate for chronic diastolic dysfunction in patients with HCM.
References
Jun 1, 1978·British Heart Journal·J E SandersonJ F Goodwin
Jun 1, 1979·The Journal of Pathology·K R AndersonJ T Lie
Mar 1, 1992·Journal of the American College of Cardiology·P NihoyannopoulosC M Oakley
Mar 15, 1990·Journal of the American College of Cardiology·P Spirito, B J Maron
Jul 1, 1985·Progress in Cardiovascular Diseases·E D WigleW G Williams
Oct 1, 1980·British Heart Journal·M G St John SuttonR L Frye
Oct 1, 1981·Circulation·M A QuinonesR R Miller
Jul 1, 1996·Circulation·P H PakD A Kass
Jul 12, 1997·Lancet·B J Maron
Feb 15, 2001·Circulation·D S LimA J Marian
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Barry J Maron
May 30, 2002·Circulation·Javier DíezJosé L Martínez Ubago
Dec 14, 2002·The American Journal of Cardiology·Teresa S M TsangJames B Seward
Dec 31, 2002·Journal of the American College of Cardiology·Lubna ChoudhuryRaymond J Kim
May 14, 2003·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Sep 4, 2003·Circulation·Raffaella LombardiMassimo Chiariello
May 5, 2004·Current Problems in Cardiology·Steve R Ommen, Rick A Nishimura
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Jul 2, 2005·American Heart Journal·Vandana SachdevJonathan F Plehn
Jul 16, 2005·Heart·J C MoonW J McKenna
Nov 29, 2005·The American Journal of Cardiology·Aloir Queiroz AraujoCharles Mady
Citations
Jun 10, 2014·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Francisca CaetanoAntónio Leitão Marques
Dec 21, 2010·Heart Failure Reviews·Mouaz H Al-Mallah, Mohammad Naseem Shareef
Dec 27, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Seiji Takashima
Sep 5, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuji NanjoJunichi Yamazaki
Jan 25, 2012·European Heart Journal Cardiovascular Imaging·Makoto SaitoJitsuo Higaki
Feb 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTsutomu Yoshikawa
Nov 3, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Woo-In YangJong-Won Ha
May 20, 2015·Journal of cardiology·Chunhua WangFabao Gao
Sep 6, 2011·Journal of cardiology·Ayumi NojiriMichihiro Yoshimura
May 24, 2015·European Journal of Radiology·You-Zhou ChenChang-Lin Zhang
Mar 19, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Damiano MagrìCamillo Autore
Sep 1, 2012·Journal of the American College of Cardiology·Giancarlo TodiereMassimo Lombardi
Jun 7, 2011·American Heart Journal·Maria Rosa ConteFiorenzo Gaita
Jan 19, 2015·European Radiology·Yinsu ZhuJae Hyung Park
Dec 21, 2016·Journal of Computer Assisted Tomography·Linda C ChuStefan L Zimmerman
Nov 6, 2010·Journal of Cardiovascular Pharmacology·Makoto SaitoJitsuo Higaki