Extent of late gadolinium enhancement in cardiovascular magnetic resonance and its relation with left ventricular diastolic function in patients with hypertrophic cardiomyopathy

Circulation Journal : Official Journal of the Japanese Circulation Society
Dae-Sik ChoiNamsik Chung

Abstract

The aim of this study was to determine whether the extent of late gadolinium enhancement (LGE) is associated with left ventricular (LV) function in patients with hypertrophic cardiomyopathy (HCM). Forty-seven patients with HCM (35 males, mean age 53+/-14, 14 with LV outflow tract obstruction) underwent cardiovascular magnetic resonance imaging and comprehensive echocardiographic examination. The extent of LGE was expressed as LGE volume and LGE percentage of LV volume. LGE was present in 40 (85.1%) of 47 patients. The mean LGE volume was 36.5+/-36 cm3, and the mean percentage of LV volume was 16.4+/-17%. Following adjustment for age, mitral regurgitation and LV mass index, LGE volume and percentage positively correlated with the left atrial volume index (r=0.388, p=0.009 and r=0.425, p=0.004, respectively). However, there was no significant association of functional class, ejection fraction, mitral flow, or annular velocities with the extent of LGE. In HCM patients, the extent of LGE positively correlated with the left atrial volume index, a surrogate marker of chronic diastolic burden. These findings suggest that myocardial scarring may be a pathologic substrate for chronic diastolic dysfunction in patients with HCM.

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Citations

Jun 10, 2014·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Francisca CaetanoAntónio Leitão Marques
Dec 21, 2010·Heart Failure Reviews·Mouaz H Al-Mallah, Mohammad Naseem Shareef
Dec 27, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Seiji Takashima
Sep 5, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuji NanjoJunichi Yamazaki
Feb 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTsutomu Yoshikawa
Nov 3, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Woo-In YangJong-Won Ha
Mar 19, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Damiano MagrìCamillo Autore
Sep 1, 2012·Journal of the American College of Cardiology·Giancarlo TodiereMassimo Lombardi
Dec 21, 2016·Journal of Computer Assisted Tomography·Linda C ChuStefan L Zimmerman

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