PMID: 11932943Apr 5, 2002Paper

Extent of retinal ganglion cell death in the frog Litoria moorei after optic nerve regeneration induced by lesions of different sizes

The Journal of Comparative Neurology
S A DunlopL D Beazley

Abstract

Some amphibian retinal ganglion cells die during optic nerve regeneration. Here we have investigated whether ganglion cell death in the frog Litoria moorei is associated with the lesion site. For one experimental series, the optic nerve lesion extended for 0.15 mm; in the other, it extended for 1.5 mm. The extent of ganglion cell death was estimated from cresyl violet-stained whole mounts at 24 weeks post lesion. In other animals, individual regenerating axons were visualised in the optic nerve by horseradish peroxidase (HRP) labelling from 1 day to 24 weeks post lesion; counterstaining with cresyl violet allowed examination of cells that repopulated the lesion site. Ganglion cell numbers fell significantly more after an extensive than after a localised lesion, long-term losses being 50% and 34%, respectively (P < 0.05). Regenerating axons were delayed in their passage across the cell-poor extensive lesion compared with the relatively cell-rich localised lesion. The differing rates of regeneration between series were matched by greater delay after extensive lesion in the return of visually guided behaviour as assessed by optokinetic horizontal head nystagmus. We suggest that delays in regeneration after an extensive lesion exac...Continue Reading

References

May 1, 1979·Biological Reviews of the Cambridge Philosophical Society·J A Kiernan
Jun 15, 1990·The Journal of Comparative Neurology·P A Trimmer, R E Wunderlich
Jun 15, 1985·The Journal of Comparative Neurology·M F Humphrey, L D Beazley
Dec 1, 1986·Neurochemical Pathology·D J StelznerJ A Strauss
Jan 1, 1972·Brain, Behavior and Evolution·G Lázár
Jan 1, 1973·Brain, Behavior and Evolution·D Bowsher
May 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·P S SharpE M Kohner
Aug 20, 1982·The Journal of Comparative Neurology·M MurrayM A Edwards
Oct 20, 1981·The Journal of Comparative Neurology·S A Dunlop, L D Beazley
Feb 7, 1998·Cell and Tissue Research·S A Dunlop
May 13, 1999·Neuroreport·E VerdúM Nieto-Sampedro
Dec 10, 1999·Molecular and Cellular Neurosciences·A Meyer-FrankeB A Barres
Mar 31, 2000·Nature Medicine·G Raisman
May 18, 2000·Journal of Neuroimmunology·G MoalemM Schwartz
Jun 9, 2000·Annual Review of Neuroscience·J L Goldberg, B A Barres
Aug 5, 2000·Progress in Retinal and Eye Research·H K Yip, K F So
Oct 1, 1951·Journal of Experimental Psychology·J DEESE, J A CARPENTER

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Citations

Mar 31, 2015·Neurological Research·Hou-Bin HuangZhi-Zhong Ma
Sep 16, 2004·The Journal of Comparative Neurology·Sarah A DunlopLyn D Beazley
Sep 11, 2003·The Journal of Comparative Neurology·Sarah A Dunlop
Dec 22, 2006·The Journal of Comparative Neurology·Sarah A DunlopLyn D Beazley
Sep 6, 2019·International Journal of Molecular Sciences·Marie ClaesLieve Moons
Oct 1, 2009·Clinical & Experimental Ophthalmology·Nitza Goldenberg-CohenDov Weinberger

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