Extent of Spine Deformity Predicts Lung Growth and Function in Rabbit Model of Early Onset Scoliosis

PloS One
J Casey OlsonBrian D Snyder

Abstract

Early onset deformity of the spine and chest wall (initiated <8 years of age) is associated with increased morbidity at adulthood relative to adolescent onset deformity of comparable severity. Presumably, inhibition of thoracic growth during late stage alveolarization leads to an irreversible loss of pulmonary growth and thoracic function; however the natural history of this disease from onset to adulthood has not been well characterized. In this study we establish a rabbit model of early onset scoliosis to establish the extent that thoracic deformity affects structural and functional respiratory development. Using a surgical right unilateral rib-tethering procedure, rib fusion with early onset scoliosis was induced in 10 young New Zealand white rabbits (3 weeks old). Progression of spine deformity, functional residual capacity, total lung capacity, and lung mass was tracked through longitudinal breath-hold computed tomography imaging up to skeletal maturity (28 weeks old). Additionally at maturity forced vital capacity and regional specific volume were calculated as functional measurements and histo-morphometry performed with the radial alveolar count as a measure of acinar complexity. Data from tethered rib rabbits were compa...Continue Reading

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Citations

Jan 10, 2016·Current Problems in Pediatric and Adolescent Health Care·Oscar MayerGregory Redding
Dec 31, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian R D'AndreaSriram Balasubramanian
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May 22, 2021·Seminars in Musculoskeletal Radiology·Riccardo GuglielmiPaolo Simoni

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