External Aortic Root Support to Prevent Aortic Dilatation in Patients With Marfan Syndrome

Journal of the American College of Cardiology
C IzgiR H Mohiaddin

Abstract

Personalized external aortic root support (PEARS) was introduced in 2004 for prevention of aortic root dilatation in Marfan patients. The individual's aortic root is replicated by 3-dimensional printing. A polymer mesh sleeve is manufactured, which is implanted with the aim to support and stabilize the aortic wall. The aim of this study was to assess effectiveness of PEARS for prevention of aortic root dilatation in Marfan patients. A total of 24 consecutive Marfan patients operated 2004 to 2012 were prospectively monitored with magnetic resonance imaging. Following a pre-defined protocol, baseline and follow-up aorta measurements were made in a blinded random sequence. The mean age of the patients was 33 ± 13.3 years (range: 16 to 58 years), and the mean aortic root diameter was 45 ± 2.8 mm (range: 41 to 52 mm). Follow-up was 6.3 ± 2.6 years. There was no increase in the aortic root and ascending aorta diameters, but there was a tendency toward reduction: annulus diameter 28.9 ± 2.3 mm to 28.5 ± 2.4 mm (change -0.39 mm, 95% confidence interval [CI]: -1.05 to 0.27 mm), sinus of Valsalva diameter 44.9 ± 2.9 mm to 44.5 ± 3.0 mm (change -0.37 mm, 95% CI: -1.23 to 0.51 mm), and ascending aorta diameter 32.4 ± 3.6 mm to 32.3 ± 3.7 m...Continue Reading

Citations

May 23, 2019·European Heart Journal·Xun Yuan, Christoph Nienaber
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Navid T SaidyElena M De-Juan-Pardo
Feb 19, 2020·Scientific Reports·Emma VandervekenFilip Rega
Aug 8, 2020·Interactive Cardiovascular and Thoracic Surgery·Petr NemecPetr Fila
Mar 19, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Pauline ArnaudGuillaume Jondeau
Apr 24, 2021·The Journal of Thoracic and Cardiovascular Surgery·Lucas Van HoofJohn Pepper
Nov 4, 2020·The Journal of Thoracic and Cardiovascular Surgery·Edward Buratto, Igor E Konstantinov
Sep 4, 2021·Nature Reviews. Disease Primers·Dianna M MilewiczReed E Pyeritz

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