External Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model

Clinical Orthopaedics and Related Research
Yongren WuVincent D Pellegrini

Abstract

External beam irradiation is an accepted treatment for skeletal malignancies. Radiation acts on both cancerous and normal cells and, depending on the balance of these effects, may promote or impair bone healing after pathologic fracture. Previous studies suggest an adverse effect of radiation on endochondral ossification, but the existence of differential effects of radiation on the two distinct bone healing pathways is unknown. The purpose of this study was to investigate the differential effects of external beam irradiation on endochondral compared with intramembranous ossification with intramedullary nail and plate fixation of fractures inducing the two respective osseous healing pathways through assessment of (1) bone biology by histomorphometric analysis of cartilage area and micro-CT volumetric assessment of the calcified callus; and (2) mechanical properties of the healing fracture by four-point bending failure analysis of bending stiffness and strength. Thirty-six male Sprague-Dawley rats underwent bilateral iatrogenic femur fracture: one side was repaired with an intramedullary nail and the other with compression plating. Three days postoperatively, half (n = 18) received 8-Gray external beam irradiation to each fractu...Continue Reading

References

May 1, 1978·The Journal of Bone and Joint Surgery. British Volume·B McKibbin
Nov 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R K BrownM M Panjabi
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A MarkbreiterM M Panjabi
Jul 1, 1985·Acta Radiologica. Oncology·M JacobssonI Turesson
Dec 1, 1970·Health Physics·H Q Woodard
May 1, 1967·Radiology·B C Bonarigo, P Rubin
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R R PelkerA Doganis
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F Bonnarens, T A Einhorn
May 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R F WidmannR E Peschel
Apr 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D W KlotchA Slater-Haase
Dec 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S DijkstraT Wiggers
Sep 25, 1998·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M J Mitchell, P M Logan
Jan 26, 1999·Clinical Orthopaedics and Related Research·T A Einhorn
Jan 5, 2002·Archives of Orthopaedic and Trauma Surgery·M Bhandari, S Shaughnessy
Aug 8, 2002·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S Larsson
Jan 31, 2004·Bone·K H SzymczykC S Adams
Oct 2, 2004·The Oncologist·Robert E Coleman
Oct 21, 2005·European Radiology·H J Williams, A M Davies
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert E Coleman
Oct 12, 2007·Journal of Radiation Research·Tomonori SakuraiJunji Miyakoshi
Jan 29, 2008·Injury·Peter V GiannoudisDavid Marsh
May 9, 2008·Calcified Tissue International·Peter VestergaardLeif Mosekilde
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hamed Al HusainiFrances A Shepherd
Jun 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Jacob BickelsZvi Lidar
Aug 25, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Filippo De MarinisJean Trédaniel
Mar 17, 2010·Radiation and Environmental Biophysics·Patrick LauGünther Reitz
Oct 16, 2010·Injury·Pietro RuggieriMario Mercuri
Dec 15, 2010·The Journal of Clinical Endocrinology and Metabolism·R J Santen
Jan 5, 2011·Nature Reviews. Endocrinology·Larry J SuvaRobert J Griffin
Oct 1, 2011·The Journal of Craniofacial Surgery·Jie HeYue He
Mar 22, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Larry J Suva, Robert J Griffin
Apr 23, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fred NichollsPeter Ferguson
May 1, 2013·Plastic and Reconstructive Surgery·Alexis DonneysSteven R Buchman
Oct 16, 2013·International Orthopaedics·Camilla ArviniusLuis López-Durán Stern
Oct 29, 2013·Vascular Cell·Peter Grabham, Preety Sharma
Dec 19, 2014·Radiation Oncology·Elina Korpela, Stanley K Liu

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Citations

Jan 16, 2021·International Orthopaedics·Matthew R ClaxtonMatthew T Houdek
Jul 14, 2021·Der Unfallchirurg·H EggersP Ivanyi

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