External beam radiation therapy and abiraterone in men with localized prostate cancer: safety and effect on tissue androgens

International Journal of Radiation Oncology, Biology, Physics
Eunpi ChoR Bruce Montgomery

Abstract

Optimizing androgen suppression may provide better control of localized prostate cancer (PCa). Numerous trials have supported the benefit of combining androgen deprivation therapy with definitive radiation therapy in men with locally advanced or high-grade disease. Addition of abiraterone to luteinizing hormone-releasing hormone agonist (LHRHa) with radiation has not been reported. We examined the safety of this combination as well as its impact on androgen suppression. A prospective, phase 2 study was conducted in men with localized PCa treated with 6 months of neoadjuvant and concurrent abiraterone with LHRHa and radiation. Duration of adjuvant LHRHa was at the discretion of the treating clinician. Prostate biopsy assays were obtained prior to the start of therapy and prior to radiation. Sera and tissue androgen levels were measured by liquid chromatography-tandem mass spectrometry. A total of 22 men with intermediate- (n=3) and high-risk PCa (n=19) received study therapy. Sixteen men completed the intended course of abiraterone, and 19 men completed planned radiation to 77.4 to 81 Gy. Radiation to pelvic nodes was administered in 20 men. The following grade 3 toxicities were reported: lymphopenia (14 patients), fatigue (1 pa...Continue Reading

Associated Clinical Trials

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Citations

Mar 13, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S BellefqihN Benjaafar
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Eunpi ChoBruce Montgomery
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Tapesh BhattacharyyaGeetha Muttath
Sep 21, 2016·Prostate Cancer and Prostatic Diseases·S M GreenE A Mostaghel
Jul 1, 2017·Endocrine-related Cancer·Tianzhu ZangTrevor M Penning
Mar 5, 2016·Der Urologe. Ausg. A·A Heidenreich, D Böhmer
May 17, 2018·Nature Reviews. Urology·Géraldine PignotDelphine Borchiellini
Jul 18, 2017·Current Urology Reports·Bradley C HollandShaheen Alanee
Apr 9, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elahe A MostaghelR Bruce Montgomery
Sep 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elahe A MostaghelPeter S Nelson
Sep 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rana R McKayMary-Ellen Taplin
Aug 2, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·André G GouveiaMauricio F Silva

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