PMID: 9442775Jan 27, 1998Paper

External beam radiation therapy for choroidal neovascularization

Ophthalmology
R F SpaideD Abramson

Abstract

This study aimed to determine the effect of external beam radiation therapy on choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). The study design was a nonrandomized clinical trial with an historic control group. A total of 91 patients were treated with external beam radiation. These patients were compared retrospectively to the 119 patients in a control group. Patients with subfoveal CNV who did not meet the criteria for laser treatment defined by published reports from the Macular Photocoagulation Study Group or who did not want laser treatment were considered for radiation therapy in a nonrandomized, prospective clinical trial. Additional entry criteria for this prospective study included visual acuity better than or equal to 20/320 on the Early Treatment Diabetic Retinopathy Study chart and a lesion size less than 12 disc areas. The patients were treated with 5 fractions of 200 cGy 6 MV external beam photons. The visual acuity measured at baseline was compared to the visual acuity after 1 year of follow-up. The mean baseline visual acuity of the 91 patients entered into the Radiation Study was 20/80. After 1 year, 83 patients (91.2%) completed follow-up, and their mean visual acuity dro...Continue Reading

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Citations

Mar 20, 2004·Irish Journal of Medical Science·S Byrne, S Beatty
Jan 9, 2004·Survey of Ophthalmology·Antonio P CiardellaLawrence A Yannuzzi
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