PMID: 11319284Apr 25, 2001Paper

External beam radiotherapy and intraluminal brachytherapy in advanced inoperable esophageal cancer: JIPMER experience

American Journal of Clinical Oncology
S VivekanandamM Nachiappan

Abstract

From January 1994 to September 1998, all inoperable cases of cancer of the esophagus at Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India were given external beam radiotherapy (EBRT) 36 Gy/18 times by anteroposterior pair. After EBRT, those patients who could be intubated with 16 F Levine's tube either directly or after endoscopic dilatation were given intraluminal brachytherapy (ILBT) 36 Gy in 48 hours at 1 cm. Others were treated by EBRT by posterior oblique fields 24 Gy/12 times. Fifty-eight patients who received EBRT and ILBT formed the study group. Fifty percent had middle one third growth and except for three, all were squamous cell carcinoma (95%). Fifty-nine percent required postradiation endoscopic dilatation. The overall survival rate was 24% at the end of 1 year. In one patient, tracheoesophageal fistula developed 4 months after treatment. Mild-to-moderate acute esophagitis developed in 10% of the patients, and 2% had slight hemoptysis, but these were not significant enough to interrupt treatment. There was no treatment-related mortality. Thirty-four patients (59%) were followed up for 6 months to 5 years (mean, 9.6 months). Three patients had follow-up of more than 3 ye...Continue Reading

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Citations

Feb 11, 2005·Current Opinion in Gastroenterology·Anthony Watson
Apr 2, 2015·The Indian Journal of Surgery·N R Vishnu PrasadK S Reddy
Oct 28, 2016·Annals of the New York Academy of Sciences·Yongjing LiuXiaoxin Luke Chen

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